Gene

dhx8

ID

ZDB-GENE-050809-39

Name

DEAH (Asp-Glu-Ala-His) box polypeptide 8

Symbol

dhx8 Nomenclature History

Previous Names

im:7153552

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Involved in cell division; mRNA splicing, via endonucleolytic cleavage and ligation; and primitive hemopoiesis. Localizes to nucleus. Is expressed in brain; midbrain; and pronephric duct. Orthologous to human DHX8 (DEAH-box helicase 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7153552 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from English et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dhx8 Human Ortholog

No data available

Associated With dhx8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR003029	S1 domain
Domain	IPR007502	Helicase-associated domain
Domain	IPR011709	DEAD-box helicase, OB fold
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR044762	DHX8/ Prp22, DEXH-box helicase domain
Domain	IPR048333	Helicase associated domain (HA2), winged-helix domain
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	DEAD-box helicase, OB fold	DHX8/ Prp22, DEXH-box helicase domain	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	Helicase-associated domain	Helicase associated domain (HA2), winged-helix domain	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	Nucleic acid-binding, OB-fold	P-loop containing nucleoside triphosphate hydrolase	S1 domain
UniProtKB:A0A8M9Q925 InterPro	1210

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dhx8-201 (1) Ensembl	Havana	4437 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations