Gene
tnfb
- ID
- ZDB-GENE-050601-2
- Name
- tumor necrosis factor b (TNF superfamily, member 2)
- Symbol
- tnfb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity and tumor necrosis factor receptor binding activity. Involved in liver development. Predicted to localize to extracellular space and integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Is expressed in several structures, including digestive system; heart; integument; musculature system; and pleuroperitoneal region. Orthologous to several human genes including LTA (lymphotoxin alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Qi et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| asthma | Alliance | {Asthma, susceptibility to} | 600807 |
| migraine | Alliance | {Migraine without aura, susceptibility to} | 157300 |
| ?Immunodeficiency 127 | 620977 | ||
| {Dementia, vascular, susceptibility to} | |||
| {Malaria, cerebral, susceptibility to} | 611162 | ||
| {Septic shock, susceptibility to} |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Lymphotoxin-alpha | Tumour necrosis factor | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q4W898
|
242 |
Interactions and Pathways
No data available
Plasmids