Gene

tnfb

ID
ZDB-GENE-050601-2
Name
tumor necrosis factor b (TNF superfamily, member 2)
Symbol
tnfb Nomenclature History
Previous Names
  • TNF2 (1)
  • tnf
  • lta (1)
  • TNF-alpha 2 (1)
  • Tnf-alpha (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have tumor necrosis factor receptor binding activity. Involved in liver development. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; heart; integument; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to several human genes including LTA (lymphotoxin alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 22 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Qi et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnfb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma Alliance {Asthma, susceptibility to} 600807
migraine Alliance {Migraine without aura, susceptibility to} 157300
{Dementia, vascular, susceptibility to}
{Malaria, cerebral, susceptibility to} 611162
{Septic shock, susceptibility to}
Associated With tnfb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006052 Tumour necrosis factor domain
Family IPR002960 Lymphotoxin-alpha
Family IPR006053 Tumour necrosis factor
Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
Domain Details Per Protein
Protein Length Lymphotoxin-alpha Tumour necrosis factor Tumour necrosis factor domain Tumour necrosis factor-like domain superfamily
UniProtKB:Q4W898 242
UniProtKB:Q1JQ40 242
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations