Gene

nxn

ID

ZDB-GENE-050522-75

Name

nucleoredoxin

Symbol

nxn Nomenclature History

Previous Names

ns:zf-es94
zgc:110449

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable thioredoxin-disulfide reductase activity. Predicted to be involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to act upstream of or within Wnt signaling pathway and cell differentiation. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; brain; immature eye; lens; and neural plate. Human ortholog(s) of this gene implicated in Robinow syndrome. Orthologous to human NXN (nucleoredoxin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110449 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nxn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive Robinow syndrome 2	Alliance	Robinow syndrome, autosomal recessive 2	618529

Associated With nxn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR012336	Thioredoxin-like fold
Domain	IPR013766	Thioredoxin domain
Domain	IPR045870	TryX and NRX, thioredoxin domain
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily