Gene
six6b
- ID
- ZDB-GENE-050522-308
- Name
- SIX homeobox 6b
- Symbol
- six6b Nomenclature History
- Previous Names
-
- si:dkey-225h23.3
- zgc:110344
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables double-stranded DNA binding activity. Involved in gene expression. Acts upstream of or within camera-type eye development and cell population proliferation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; eye; and kidney. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| optic disc anomalies with retinal and/or macular dystrophy | Alliance | Optic disc anomalies with retinal and/or macular dystrophy | 212550 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox protein SIX1, N-terminal SD domain | Homeodomain |
|---|---|---|---|---|
|
UniProtKB:Q5TYZ2
|
245 |
Interactions and Pathways
No data available
Plasmids
No data available