Gene

dlg2

ID

ZDB-GENE-050221-3

Name

discs, large homolog 2 (Drosophila)

Symbol

dlg2 Nomenclature History

Previous Names

PSD-93 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable ionotropic glutamate receptor binding activity and protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to synapse; and receptor clustering. Predicted to be located in several cellular components, including axon; perikaryon; and synapse. Predicted to be active in several cellular components, including basolateral plasma membrane; neuromuscular junction; and postsynaptic density membrane. Is expressed in nervous system and neural tube. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlg2 Human Ortholog

No data available

Associated With dlg2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020590	Guanylate kinase, conserved site
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR004172	L27 domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR015143	L27-1
Domain	IPR019583	Disks large homolog 1-4, PDZ-associated domain
Domain	IPR019590	Disks large homologue 1, N-terminal PEST domain
Domain	IPR035759	Disks Large homologue 2, SH3 domain
Family	IPR016313	Disks large 1-like
Family	IPR050614	Synaptic Scaffolding LAP/MAGUK Families
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036892	L27 domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3B3D7	InterPro	858
UniProtKB:A0A8M3B6B1	InterPro	1044
UniProtKB:A0A8M3BD50	InterPro	959
UniProtKB:A0A8M3BD41	InterPro	987
UniProtKB:A0A8M3AWU6	InterPro	1068
UniProtKB:A0A8M3AWX6	InterPro	1031
UniProtKB:A0A8M3B6A6	InterPro	1065
UniProtKB:A0A8M3B6B8	InterPro	972
UniProtKB:A0A8M3B6B4	InterPro	1010
UniProtKB:A0A8M3BD31	InterPro	1075
UniProtKB:A0A8M3AWV4	InterPro	1022
UniProtKB:A0A8M9QC28	InterPro	860
UniProtKB:A0A8M3AWW9	InterPro	1075
UniProtKB:A0A8M3B3D0	InterPro	1002
UniProtKB:A0A8M3AWX1	InterPro	1060
UniProtKB:A0A8M3AWW5	InterPro	931
UniProtKB:A0A8M3BD47	InterPro	961
UniProtKB:Q5PYH7	InterPro	881
UniProtKB:A0A8M3B6C1	InterPro	925
UniProtKB:A0A8M3B3C7	InterPro	1042
UniProtKB:A0A8M3AWY5	InterPro	967
UniProtKB:A0A8M3AWY0	InterPro	987
UniProtKB:A0A8M3AWV0	InterPro	1057
UniProtKB:A0A8M3BD37	InterPro	1030
UniProtKB:A0A8M3B3C4	InterPro	1063
UniProtKB:A0A8M3B3D4	InterPro	968
UniProtKB:A0A8M3AWY7	InterPro	1040
UniProtKB:A0A8M3AWW1	InterPro	977
UniProtKB:A0A8M3B3C1	InterPro	1083
UniProtKB:A0A8M3BD36	InterPro	1059