Gene
tfr2
- ID
- ZDB-GENE-041220-3
- Name
- transferrin receptor 2
- Symbol
- tfr2 Nomenclature History
- Previous Names
-
- zgc:123043
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have transferrin receptor activity. Involved in iron ion homeostasis. Predicted to localize to integral component of membrane. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Is expressed in liver. Orthologous to human TFR2 (transferrin receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Basu et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hemochromatosis type 3 | Alliance | Hemochromatosis, type 3 | 604250 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
hemochromatosis type 3 | tfr2f6/f6 | standard conditions | Basu et al., 2018 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003137 | PA domain |
Domain | IPR007484 | Peptidase M28 |
Domain | IPR037324 | Transferrin receptor protein 1/2, PA domain |
Family | IPR039373 | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
Homologous_superfamily | IPR036757 | Transferrin receptor-like, dimerisation domain superfamily |
Homologous_superfamily | IPR046450 | PA domain superfamily |
Domain Details Per Protein
Protein | Length | PA domain | PA domain superfamily | Peptidase M28 | Transferrin receptor-like, dimerisation domain superfamily | Transferrin receptor protein 1/2, PA domain | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
---|---|---|---|---|---|---|---|
UniProtKB:A0A0G2KE94
|
778 | ||||||
UniProtKB:Q5MPX2
|
783 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available