sim1b

ID

ZDB-GENE-041210-5

Name

SIM bHLH transcription factor 1b

Symbol

sim1b Nomenclature History

Previous Names

Sim1 (1)
si:ch211-152c2.1

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in caudal tuberculum; diencephalon; hypothalamus; midbrain; and preoptic area. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Löhr et al., 2009

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sim1b Human Ortholog

No data available

Associated With sim1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000014	PAS domain
Domain	IPR010578	Single-minded, C-terminal
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR013655	PAS fold-3
Domain	IPR013767	PAS fold
Family	IPR001067	Nuclear translocator
Homologous_superfamily	IPR035965	PAS domain superfamily
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily
Repeat	IPR001610	PAC motif