Gene

mcm10

ID

ZDB-GENE-041210-42

Name

minichromosome maintenance 10 replication initiation factor

Symbol

mcm10 Nomenclature History

Previous Names

si:ch211-206k18.2

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable DNA replication origin binding activity and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within DNA replication and cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be active in nuclear replication fork. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Weinreb et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mcm10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency 80 with or without cardiomyopathy	619313

Associated With mcm10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR015408	Zinc finger, Mcm10/DnaG-type
Domain	IPR015411	Replication factor Mcm10, C-terminal
Family	IPR040184	Minichromosome maintenance protein 10
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold