Gene

cradd

ID

ZDB-GENE-041010-168

Name

CASP2 and RIPK1 domain containing adaptor with death domain

Symbol

cradd Nomenclature History

Previous Names

zgc:101717

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have death domain binding activity and protease binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity. Predicted to localize to CBM complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:101717 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cradd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 34	Alliance	Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly	614499

Associated With cradd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000488	Death domain
Domain	IPR001315	CARD domain
Domain	IPR037926	CRADD, Death domain
Domain	IPR042148	RAIDD, CARD domain
Family	IPR037939	Death domain-containing protein CRADD
Homologous_superfamily	IPR011029	Death-like domain superfamily