Gene
wdr33
- ID
- ZDB-GENE-040924-3
- Name
- WD repeat domain 33
- Symbol
- wdr33 Nomenclature History
- Previous Names
-
- FLJ11294-like (H. sapiens) (1)
- zgc:110570
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within mRNA 3'-end processing. Predicted to be located in membrane. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human WDR33 (WD repeat domain 33).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157075 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2246Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa7527 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa13555 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15874 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31252 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32835 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39758 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39759 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| yzu6Et | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Pre-mRNA 3' end processing protein Pfs2-like | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B6D6
|
1102 | ||||
|
UniProtKB:U3JAJ0
|
290 | ||||
|
UniProtKB:A0A8M2BAF0
|
1017 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-113B6 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-290F12 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7157075 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110570 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001194928 (1) | 4202 nt | ||
| Genomic | GenBank:CU571377 (2) | 26752 nt | ||
| Polypeptide | UniProtKB:A0A8M3B6D6 (1) | 1102 aa |
- Shen, D., Xue, S., Chan, S., Sang, Y., Wang, S., Wang, Y., Chen, C., Gao, B., Mueller, F., Song, C. (2018) Enhancer Trapping and Annotation in Zebrafish Mediated with Sleeping Beauty, piggyBac and Tol2 Transposons. Genes. 9(12)
- Despic, V., Dejung, M., Gu, M., Krishnan, J., Zhang, J., Herzel, L., Straube, K., Gerstein, M.B., Butter, F., Neugebauer, K.M. (2017) Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome research. 27(7):1184-1194
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kalén, M., Wallgard, E., Asker, N., Nasevicius, A., Athley, E., Billgren, E., Larson, J.D., Wadman, S.A., Norseng, E., Clark, K.J., He, L., Karlsson-Lindahl, L., Häger, A.K., Weber, H., Augustin, H., Samuelsson, T., Kemmet, C.K., Utesch, C.M., Essner, J.J., Hackett, P.B., and Hellström, M. (2009) Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Chemistry & Biology. 16(4):432-441
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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