Gene
lingo1b
- ID
- ZDB-GENE-040912-136
- Name
- leucine rich repeat and Ig domain containing 1b
- Symbol
- lingo1b Nomenclature History
- Previous Names
-
- lingo1
- zgc:92338 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor receptor binding activity. Acts upstream of or within myelination and neuron development. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in basal plate midbrain region; nervous system; neural plate; presumptive diencephalon; and presumptive telencephalon. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0317 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Yin et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 64 | Alliance | Intellectual developmental disorder, autosomal recessive 64 | 618103 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR050541 | Leucine-rich repeat and transmembrane domain-containing protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR026906 | BspA-type LRR region |
Domain Details Per Protein
| Protein | Length | BspA-type LRR region | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Leucine-rich repeat | Leucine-rich repeat and transmembrane domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66HV9
|
622 | ||||||||||||
|
UniProtKB:A0A8M2BE21
|
621 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lingo1b-201
(1)
|
Ensembl | 3,128 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| ab1-lingo1b | polyclonal | Rabbit |
|
1 |
Plasmids
No data available