ZFIN ID: ZDB-GENE-040912-136
Gene Name: leucine rich repeat and Ig domain containing 1b
Gene Symbol: lingo1b
Sequence Ontology ID : SO:0000704

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Previous Names: lingo1, zgc:92338 (1)

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in myelination and neuron development; predicted to localize to the extracellular matrix and extracellular space; orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1).
GENE EXPRESSION
All Expression Data: 10 figures from 4 publications
Directly Submitted Expression Data: 7 figures (25 images) from Thisse et al., 2008 [cssl:d0317]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Juvenile:Days 30-44 (30d-45d, 10 mm, adult fins/pigment)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40997 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 4 figures from Yin et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH lingo1b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal recessive 64 618103
    Mental retardation, autosomal recessive 64 618103
    DISEASE ASSOCIATED WITH lingo1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myelination (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000372 (1)
  • InterPro:IPR001611 (1)
  • InterPro:IPR003591 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR026906 (1)
  • InterPro:IPR032675 (1)
  • InterPro:IPR036179 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF13306 (1)
  • Pfam:PF13855 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lingo1b-201 (1) 3128
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM lingo1b No data available
    MARKER RELATIONSHIPS
    lingo1bContained in: [BAC] CH211-116A8 (1) (order this)
    lingo1bEncodes: [EST] cssl:d0317 (1) (order this)
    [cDNA] MGC:92338 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001004576 (1) 3160bp
    Genomic GenBank:BX470207 (1) 60832bp
    Select Tool
    Polypeptide UniProtKB:Q66HV9 (1) 622aa
    Sequence Clusters UniGene:12903 (1)
    Sequence Information (all 19)
    OTHER lingo1b GENE PAGES
  • Alliance (1)
  • Gene:447837 (1)
  • VEGA:OTTDARG00000022162 (1)
  • Ensembl(GRCz11):ENSDARG00000035899 (2)
  • ORTHOLOGY for lingo1b (Chr: 7)
    CITATIONS (30)