ZFIN ID: ZDB-GENE-040912-136
Gene Name: leucine rich repeat and Ig domain containing 1b
Gene Symbol: lingo1b    Nomenclature History

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Previous Names: lingo1, zgc:92338 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have epidermal growth factor receptor binding activity. Involved in myelination and neuron development. Predicted to localize to extracellular matrix and extracellular space. Is expressed in basal plate midbrain region; nervous system; neural plate; presumptive diencephalon; and presumptive telencephalon. Human ortholog(s) of this gene implicated in glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1).
Genome Resources: Alliance (1),  Gene:447837 (1),  Ensembl(GRCz11):ENSDARG00000035899 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40997 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lingo1b N/A 1
    MO2-lingo1b N/A 1
    MO3-lingo1b N/A 1
    DISEASE ASSOCIATED WITH lingo1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal recessive 64 618103
    DISEASE ASSOCIATED WITH lingo1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myelination (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lingo1b-201 (1)    Ensembl 3128
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    ab1-lingo1b polyclonal Rabbit WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lingo1b No data available
    MARKER RELATIONSHIPS
    lingo1b Contained in: [BAC] CH211-116A8 (1)
    lingo1b Encodes: [EST] cssl:d0317 (1)
    [cDNA] MGC:92338 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004576 (1) 3160 nt
    Genomic GenBank:BX470207 (1) 60832 nt
    Select Tool
    Polypeptide UniProtKB:Q66HV9 (1) 622 aa
    Sequence Information (all 18)
    ORTHOLOGY for lingo1b ( Chr: 7 )
    CITATIONS (34)