Gene
rela
- ID
- ZDB-GENE-040825-4
- Name
- v-rel avian reticuloendotheliosis viral oncogene homolog A
- Symbol
- rela Nomenclature History
- Previous Names
-
- nfkb3
- p65 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in anterior/posterior axis specification; mesoderm development; and regulation of apoptotic process. Localizes to nucleus. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Autoinflammatory disease, familial, Behcet-like-3 | 618287 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030492 | Rel homology domain, conserved site |
| Domain | IPR002909 | IPT domain |
| Domain | IPR011539 | Rel homology domain, DNA-binding domain |
| Domain | IPR030495 | Transcription factor p65, RHD domain, N-terminal |
| Domain | IPR032397 | Rel homology dimerisation domain |
| Domain | IPR033926 | NFkappaB IPT domain |
| Family | IPR000451 | NF-kappa-B/Dorsal |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | NF-kappa-B/Dorsal | NFkappaB IPT domain | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, conserved site | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily | Transcription factor p65, RHD domain, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DHW2
|
455 | |||||||||||
|
UniProtKB:A0A8M2BI19
|
588 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available