ZFIN ID: ZDB-GENE-040825-4
Gene Name: v-rel avian reticuloendotheliosis viral oncogene homolog A
Gene Symbol: rela    Nomenclature History

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Previous Names: nfkb3, p65 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in anterior/posterior axis specification; mesoderm development; and regulation of apoptotic process. Localizes to nucleus. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit).
Genome Resources: Alliance (1),  Gene:415099 (1),  Ensembl(GRCz11):ENSDARG00000098696 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 8 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb651 Insertion Unknown Unknown CRISPR
ihb652 Small Deletion Unknown Unknown CRISPR
sa20841 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33990 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-rela
    1
    CRISPR2-rela
    1
    CRISPR3-rela
    1
    CRISPR4-rela
    1
    CRISPR5-rela
    1
    CRISPR6-rela 1
    MO1-rela N/A 4
    MO2-rela N/A 1
    DISEASE ASSOCIATED WITH rela HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Mucocutaneous ulceration, chronic 618287
    DISEASE ASSOCIATED WITH rela VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of apoptotic process (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rela-002 (1) 7225
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-rela polyclonal IgG Rabbit Thermo Fisher Scientific (Lab Vision)
    2
    Ab1-rela polyclonal IgG Rabbit IHC Abcam plc
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rela No data available
    MARKER RELATIONSHIPS
    rela Contained in: [Fosmid] ZFOS-1464C3 (1)
    rela Encodes: [cDNA] MGC:194332 (1), MGC:194343 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001839 (1) 1753 nt
    Genomic GenBank:CU896668 (1) 43773 nt
    Select Tool
    Polypeptide UniProtKB:B3DHW2 (1) 455 aa
    Sequence Information (all 21)
    ORTHOLOGY for rela ( Chr: 7 )
    CITATIONS (77)