Gene

her12

ID

ZDB-GENE-040824-5

Name

hairy-related 12

Symbol

her12 Nomenclature History

Previous Names

Hes5c (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in Notch signaling pathway; brain development; and somitogenesis. Predicted to localize to nucleus. Is expressed in several structures, including mesoderm; nervous system; neural plate; tail bud; and trunk vasculature. Orthologous to human HES5 (hes family bHLH transcription factor 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6904047 (35 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With her12 Human Ortholog

No data available

Associated With her12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003650	Orange domain
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily