Gene

crbn

ID

ZDB-GENE-040822-43

Name

cereblon

Symbol

crbn Nomenclature History

Previous Names

zgc:92404 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Involved in embryonic pectoral fin morphogenesis; limb development; and otic vesicle morphogenesis. Localizes to ubiquitin ligase complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Orthologous to human CRBN (cereblon).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92404 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With crbn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 2	Alliance	Intellectual developmental disorder, autosomal recessive 2	607417

Associated With crbn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003111	Lon protease, N-terminal domain
Domain	IPR004910	Yippee/Mis18/Cereblon
Domain	IPR034750	CULT domain
Homologous_superfamily	IPR015947	PUA-like superfamily
Homologous_superfamily	IPR046336	Lon protease, N-terminal domain superfamily