Gene
crbn
- ID
- ZDB-GENE-040822-43
- Name
- cereblon
- Symbol
- crbn Nomenclature History
- Previous Names
-
- zgc:92404 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Involved in fin development; limb development; and otic vesicle development. Acts upstream of with a positive effect on cell population proliferation. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92404 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa40758 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-crbn | (2) | |
| CRISPR2-crbn | (2) | |
| CRISPR3-crbn | Shen et al., 2021 | |
| CRISPR4-crbn | Shen et al., 2021 | |
| CRISPR5-crbn | Shen et al., 2021 | |
| MO1-crbn | N/A | (2) |
| MO2-crbn | N/A | Ando et al., 2019 |
| MO3-crbn | N/A | Ando et al., 2019 |
1 - 8 of 8
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 2 | Alliance | Intellectual developmental disorder, autosomal recessive 2 | 607417 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CULT domain | Lon protease, N-terminal domain | Lon protease, N-terminal domain superfamily | PUA-like superfamily | Yippee/Mis18/Cereblon |
|---|---|---|---|---|---|---|---|
| UniProtKB:B2GQH0 | InterPro | 431 | |||||
| UniProtKB:A0A8M9QFB5 | InterPro | 402 | |||||
| UniProtKB:Q68EH9 | InterPro | 431 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28N18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92404 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191908 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003996 (1) | 2510 nt | ||
| Genomic | GenBank:BX936393 (2) | 204873 nt | ||
| Polypeptide | UniProtKB:B2GQH0 (1) | 431 aa |
- Shen, C., Nayak, A., Neitzel, L.R., Adams, A.A., Silver-Isenstadt, M., Sawyer, L.M., Benchabane, H., Wang, H., Bunnag, N., Li, B., Wynn, D.T., Yang, F., Garcia-Contreras, M., Williams, C.H., Dakshanamurthy, S., Hong, C.C., Ayad, N.G., Capobianco, A.J., Ahmed, Y., Lee, E., Robbins, D.J. (2021) The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nature communications. 12:5263
- Ando, H., Sato, T., Ito, T., Yamamoto, J., Sakamoto, S., Nitta, N., Asatsuma-Okumura, T., Shimizu, N., Mizushima, R., Aoki, I., Imai, T., Yamaguchi, Y., Berk, A.J., Handa, H. (2019) Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience. 15:95-108
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y., and Handa, H. (2010) Identification of a primary target of thalidomide teratogenicity. Science (New York, N.Y.). 327(5971):1345-1350
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 6 of 6
Show