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ZIRC
ZFIN ID: ZDB-GENE-040822-43
Gene Name: cereblon
Gene Symbol: crbn
Sequence Ontology ID : SO:0000704

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Previous Name: zgc:92404 (1)

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have metal ion binding activity. Involved in embryonic pectoral fin morphogenesis; limb development; and otic vesicle morphogenesis. Localizes to the ubiquitin ligase complex. Human  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92404]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40758 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH crbn HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal recessive non-syndromic intellectual disability Mental retardation, autosomal recessive 2 607417
    DISEASE ASSOCIATED WITH crbn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic pectoral fin morphogenesis (more)
    Cellular Component ubiquitin ligase complex (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA crbn-201 (1) 2526
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM crbn No data available
    MARKER RELATIONSHIPS
    crbnContained in: [BAC] DKEY-28N18 (1) (order this)
    crbnEncodes: [cDNA] MGC:92404 (1) (order this), MGC:191908 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003996 (1) 2510bp
    Genomic GenBank:BX936393 (1) 204873bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QCS1 (1) 446aa
    Sequence Clusters UniGene:84847 (1)
    Sequence Information (all 18)
    ORTHOLOGY for crbn (Chr: 6)
    CITATIONS (22)