Gene
pls3
- ID
- ZDB-GENE-040718-10
- Name
- plastin 3 (T isoform)
- Symbol
- pls3 Nomenclature History
- Previous Names
-
- wu:fc04g03
- zgc:91903
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; motor neuron axon guidance; and pronephros development. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human PLS3 (plastin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pls3 | (3) | |
| CRISPR2-pls3 | Naert et al., 2020 | |
| CRISPR3-pls3 | Naert et al., 2020 | |
| MO1-pls3 | N/A | (2) |
| MO2-pls3 | N/A | (4) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Actinin-type actin-binding domain, conserved site | Calponin homology domain | CH domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Fimbrin/Plastin |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DG81
|
627 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-201A19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-35N12 | ZFIN Curated Data | |
| Encodes | EST | fc04g03 | ||
| Encodes | cDNA | MGC:91903 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191150 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002326 (1) | 2450 nt | ||
| Genomic | GenBank:BX511270 (2) | 246560 nt | ||
| Polypeptide | UniProtKB:Q6DG81 (1) | 627 aa |
- Zhong, W., Neugebauer, J., Pathak, J.L., Li, X., Pals, G., Zillikens, M.C., Eekhoff, E.M.W., Bravenboer, N., Zhang, Q., Hammerschmidt, M., Wirth, B., Micha, D. (2024) Functional Insights in PLS3-Mediated Osteogenic Regulation. Cells. 13(17):
- Fédou, C., Camus, M., Lescat, O., Feuillet, G., Mueller, I., Ross, B., Buléon, M., Neau, E., Alves, M., Goudounéche, D., Breuil, B., Boizard, F., Bardou, Q., Casemayou, A., Tack, I., Dreux, S., Batut, J., Blader, P., Burlet-Schiltz, O., Decramer, S., Wirth, B., Klein, J., Saulnier-Blache, J.S., Buffin-Meyer, B., Schanstra, J.P. (2021) Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies Plastin 3 as a protein involved in glomerular integrity. The Journal of pathology. 254(5):575-588
- Naert, T., Tulkens, D., Edwards, N.A., Carron, M., Shaidani, N.I., Wlizla, M., Boel, A., Demuynck, S., Horb, M.E., Coucke, P., Willaert, A., Zorn, A.M., Vleminckx, K. (2020) Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos. Scientific Reports. 10:14662
- Boel, A., De Saffel, H., Steyaert, W., Callewaert, B., De Paepe, A., Coucke, P.J., Willaert, A. (2018) CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments. Disease models & mechanisms. 11(10)
- Kell, M.J., Riccio, R.E., Baumgartner, E.A., Compton, Z.J., Pecorin, P.J., Mitchell, T.A., Topczewski, J., LeClair, E.E. (2018) Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1). PLoS One. 13:e0190353
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Boel, A., Steyaert, W., De Rocker, N., Menten, B., Callewaert, B., De Paepe, A., Coucke, P., Willaert, A. (2016) BATCH-GE: Batch analysis of Next-Generation Sequencing data for genome editing assessment. Scientific Reports. 6:30330
- Chatterjee, A., Lagisz, M., Rodger, E.J., Zhen, L., Stockwell, P.A., Duncan, E.J., Horsfield, J.A., Jeyakani, J., Mathavan, S., Ozaki, Y., Nakagawa, S. (2016) Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive' hypothesis. Gene. 590(2):307-16
- Hosseinibarkooie, S., Peters, M., Torres-Benito, L., Rastetter, R.H., Hupperich, K., Hoffmann, A., Mendoza-Ferreira, N., Kaczmarek, A., Janzen, E., Milbradt, J., Lamkemeyer, T., Rigo, F., Bennett, C.F., Guschlbauer, C., Büschges, A., Hammerschmidt, M., Riessland, M., Kye, M.J., Clemen, C.S., Wirth, B. (2016) The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype. American journal of human genetics. 99(3):647-65
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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