ZFIN is now using GRCz12tu for Genomic Data

Gene

pls3

ID

ZDB-GENE-040718-10

Name

plastin 3 (T isoform)

Symbol

pls3 Nomenclature History

Previous Names

wu:fc04g03
zgc:91903

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; motor neuron axon guidance; and pronephros development. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human PLS3 (plastin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pls3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Bone mineral density QTL18, osteoporosis	300910
		Diaphragmatic hernia 5, X-linked	306950

Associated With pls3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Conserved_site	IPR001589	Actinin-type actin-binding domain, conserved site
Domain	IPR001715	Calponin homology domain
Domain	IPR002048	EF-hand domain
Family	IPR039959	Fimbrin/Plastin
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Actinin-type actin-binding domain, conserved site	Calponin homology domain	CH domain superfamily	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	Fimbrin/Plastin
UniProtKB:Q6DG81	InterPro	627

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pls3-201 (1) Ensembl	Ensembl	2,925 nt	Select Tool ZFIN BLAST
mRNA	pls3-203 (1) Ensembl	Ensembl	1,920 nt	Select Tool ZFIN BLAST
ncRNA	pls3-002 (1) Ensembl	Ensembl	653 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pls3	polyclonal	pls3		Rabbit	WB		1
Ab2-pls3	polyclonal	pls3		Rabbit	IHC	EUROGENTEC S.A.	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations