Gene

pls3

ID
ZDB-GENE-040718-10
Name
plastin 3 (T isoform)
Symbol
pls3 Nomenclature History
Previous Names
  • wu:fc04g03
  • zgc:91903
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity. Involved in bone mineralization; embryonic cranial skeleton morphogenesis; and motor neuron axon guidance. Predicted to localize to actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human PLS3 (plastin 3).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pls3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bone mineral density QTL18, osteoporosis 300910
Associated With pls3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
Domain IPR001715 Calponin homology domain
Domain IPR002048 EF-hand domain
Family IPR039956 Plastin-2/3
Family IPR039959 Fimbrin/Plastin
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR036872 CH domain superfamily
Domain Details Per Protein
Protein Length Actinin-type actin-binding domain, conserved site Calponin homology domain CH domain superfamily EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair Fimbrin/Plastin Plastin-2/3
UniProtKB:Q6DG81 627
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pls3 polyclonal Rabbit
  • WB
1
Ab2-pls3 polyclonal Rabbit
  • IHC
EUROGENTEC S.A.
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations