Gene
asic2
- ID
- ZDB-GENE-040513-4
- Name
- acid-sensing (proton-gated) ion channel 2
- Symbol
- asic2 Nomenclature History
- Previous Names
-
- zASIC2 (1)
- accn1
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ligand-gated sodium channel activity. Acts upstream of or within response to steroid hormone. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; eye; gill; olfactory rosette; and ovary. Orthologous to human ASIC2 (acid sensing ion channel subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1891 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11288 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14878 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18762 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31347 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40123 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Epithelial sodium channel | Epithelial sodium channel, chordates | Epithelial sodium channel, conserved site |
|---|---|---|---|---|---|
| UniProtKB:B3DFR3 | InterPro | 533 | |||
| UniProtKB:A0A8M2BBL3 | InterPro | 564 | |||
| UniProtKB:Q708S5 | InterPro | 533 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-asic2 | polyclonal | Rabbit |
|
LifeSpan BioSciences, Inc.
|
5 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-302K7 | ZFIN Curated Data | |
| Contained in | BAC | CH73-368I2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-15N4 | ZFIN Curated Data | |
| Contained in | BAC | CH211-202A10 | ZFIN Curated Data | |
| Contained in | BAC | CH211-261N20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-7F16 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-114A6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193635 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193662 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214788 (1) | 3160 nt | ||
| Genomic | GenBank:BX470087 (2) | 218404 nt | ||
| Polypeptide | UniProtKB:A0A8M2BBL3 (1) | 564 aa |
- Picton, L.D., Bertuzzi, M., Pallucchi, I., Fontanel, P., Dahlberg, E., Björnfors, E.R., Iacoviello, F., Shearing, P.R., El Manira, A. (2021) A spinal organ of proprioception for integrated motor action feedback. Neuron. 109(7):1188-1201.e7
- Cocco, A. (2018) The γ-aminobutyric acid and proton signaling systems in the zebrafish brain Characterization and effect of stress. Ph.D. Thesis.
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Klangnurak, W., Tokumoto, T. (2017) Fine selection of up-regulated genes during ovulation by in vivo induction of oocyte maturation and ovulation in zebrafish.. Zoological letters. 3:2
- Dymowska, A.K., Boyle, D., Schultz, A.G., Goss, G.G. (2015) The role of acid-sensing ion channels (ASICs) in epithelial Na+ uptake in adult zebrafish (Danio rerio). The Journal of experimental biology. 218(Pt 8):1244-51
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Viña, E., Parisi, V., Abbate, F., Cabo, R., Guerrera, M.C., Laurà, R., Quirós, L.M., Pérez-Varela, J.C., Cobo, T., Germanà, A., Vega, J.A., García-Suárez, O. (2015) Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish. Histochemistry and cell biology. 143(1):59-68
- Viña, E., Parisi, V., Sánchez-Ramos, C., Cabo, R., Guerrera, M.C., Quirós, L.M., Germanà, A., Vega, J.A., García-Suárez, O. (2015) Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish. Cell and tissue research. 360(2):223-31
- Dymowska, A.K., Schultz, A.G., Blair, S.D., Chamot, D., Goss, G.G. (2014) Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss. American journal of physiology. Cell physiology. 307(3):C255-65
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
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