Gene
canx
- ID
- ZDB-GENE-040426-2797
- Name
- calnexin
- Symbol
- canx Nomenclature History
- Previous Names
-
- wu:fe06b12
- zgc:63524
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within posterior lateral line development. Predicted to be located in endoplasmic reticulum; melanosome membrane; and mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including blood; fin; hatching gland; nervous system; and pleuroperitoneal region. Orthologous to human CANX (calnexin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Hung et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-canx | N/A | Hung et al., 2013 |
| MO2-canx | N/A | Hung et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calreticulin/calnexin | Calreticulin/calnexin, conserved site | Calreticulin/calnexin, P domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q7SYE1 | InterPro | 600 | ||||
| UniProtKB:F1QKS4 | InterPro | 600 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-121B13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-33H4 | ZFIN Curated Data | |
| Encodes | EST | fe06b12 | ||
| Encodes | cDNA | MGC:63524 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213448 (1) | 4220 nt | ||
| Genomic | GenBank:BX530081 (1) | 162058 nt | ||
| Polypeptide | UniProtKB:F1QKS4 (1) | 600 aa |
- Biagini, V., Busi, F., Anelli, V., Kerschbamer, E., Baghini, M., Gurrieri, E., Notarangelo, M., Pesce, I., van Niel, G., D'Agostino, V.G., Mione, M. (2022) Zebrafish Melanoma-Derived Interstitial EVs Are Carriers of ncRNAs That Induce Inflammation. International Journal of Molecular Sciences. 23(10)
- Dash, S., Trainor, P.A. (2022) Nucleolin loss of function leads to aberrant Fibroblast Growth Factor signaling and craniofacial anomalies. Development (Cambridge, England). 149(12)
- Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Grimholt, U. (2018) Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. BMC Evolutionary Biology. 18:25
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Noack Watt, K.E., Achilleos, A., Neben, C.L., Merrill, A.E., Trainor, P.A. (2016) The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome. PLoS Genetics. 12:e1006187
- Sousa, M.L., Silva, A., Malhão, F., Rocha, M.J., Rocha, E., Urbatzka, R. (2016) Reproductive hormones affect follicular cells and ooplasm of Stage I and II oocytes in zebrafish. Reproduction, fertility, and development. 28(12):1945-1952
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Howarth, D.L., Lindtner, C., Vacaru, A.M., Sachidanandam, R., Tsedensodnom, O., Vasilkova, T., Buettner, C., Sadler, K.C. (2014) Activating transcription factor 6 is necessary and sufficient for alcoholic Fatty liver disease in zebrafish. PLoS Genetics. 10:e1004335
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