Gene
amy2a
- ID
- ZDB-GENE-040426-2393
- Name
- amylase alpha 2A
- Symbol
- amy2a Nomenclature History
- Previous Names
-
- wu:fb64c06 (1)
- zgc:66270
- zgc:77877
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable alpha-amylase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in extracellular space. Is expressed in pancreas. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66270 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7487 | Allele with one point mutation | Unknown | Missense | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006047 | Glycosyl hydrolase, family 13, catalytic domain |
| Domain | IPR006048 | Alpha-amylase/branching enzyme, C-terminal all beta |
| Domain | IPR031319 | Alpha-amylase, C-terminal domain |
| Family | IPR006046 | Alpha amylase |
| Homologous_superfamily | IPR013780 | Glycosyl hydrolase, all-beta |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha amylase | Alpha-amylase/branching enzyme, C-terminal all beta | Alpha-amylase, C-terminal domain | Glycoside hydrolase superfamily | Glycosyl hydrolase, all-beta | Glycosyl hydrolase, family 13, catalytic domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P5J0 | InterPro | 512 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-15I15 | ZFIN Curated Data | |
| Contained in | BAC | RP71-34B6 | ||
| Encodes | EST | fb64c06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66270 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77877 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213011 (1) | 1627 nt | ||
| Genomic | GenBank:BX510342 (1) | 186711 nt | ||
| Polypeptide | UniProtKB:Q6P5J0 (1) | 512 aa |
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Yoon, B., Yeung, P., Santistevan, N., Bluhm, L., Kawasaki, K., Kueper, J., Dubielzig, R., Vanoudenhove, J., Cotney, J., Liao, E.C., Grinblat, Y. (2022) Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye. Biology Open. 11(5):
- Del Vecchio, G., Murashita, K., Verri, T., Gomes, A.S., Rønnestad, I. (2021) Leptin receptor-deficient (knockout) zebrafish: effects on nutrient acquisition. General and comparative endocrinology. 310:113832
- Venezia, O., Islam, S., Cho, C., Timme-Laragy, A.R., Sant, K.E. (2021) Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio. Toxicology and applied pharmacology. 426:115653
- Jiang, M., Yang, L., Chen, Z.G., Lai, S.S., Zheng, J., Peng, B. (2020) Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus. Microbial biotechnology. 13(4):1213-1227
- Oh, S., Park, J.T. (2019) Zebrafish model of KRAS-initiated pancreatic endocrine tumor. Animal cells and systems. 23:209-218
- Qian, L., Zhang, J., Chen, X., Qi, S., Wu, P., Wang, C., Wang, C. (2019) Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. Environmental pollution (Barking, Essex : 1987). 247:775-782
- Jacobs, H.M., Sant, K.E., Basnet, A., Williams, L.M., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere. 195:498-507
- Roy-Carson, S., Natukunda, K., Chou, H.C., Pal, N., Farris, C., Schneider, S.Q., Kuhlman, J.A. (2017) Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment. BMC Genomics. 18:290
- Sant, K.E., Jacobs, H.M., Borofski, K.A., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio. Environmental pollution (Barking, Essex : 1987). 220(Pt B):807-817
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