Gene

rad51

ID

ZDB-GENE-040426-2286

Name

RAD51 recombinase

Symbol

rad51 Nomenclature History

Previous Names

wu:fb38e12
zgc:77754

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have DNA binding activity; DNA-dependent ATPase activity; and recombinase activity. Involved in several processes, including double-strand break repair via homologous recombination; hematopoietic stem cell proliferation; and response to methylmercury. Predicted to localize to condensed nuclear chromosome. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Is expressed in brain; gill; liver; musculature system; and testis. Orthologous to human RAD51 (RAD51 recombinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77754 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rad51 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
breast cancer	Alliance	{Breast cancer, susceptibility to}	114480
Fanconi anemia complementation group R	Alliance	Fanconi anemia, complementation group R	617244
		Mirror movements 2	614508

Associated With rad51 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Fanconi anemia	rad51^{sa23805/sa23805}	standard conditions	Botthof et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR013632	DNA recombination and repair protein Rad51-like, C-terminal
Domain	IPR020587	DNA recombination and repair protein RecA, monomer-monomer interface
Domain	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain
Family	IPR011941	DNA recombination/repair protein Rad51
Family	IPR016467	DNA recombination and repair protein, RecA-like
Homologous_superfamily	IPR010995	DNA repair Rad51/transcription factor NusA, alpha-helical
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	DNA recombination and repair protein Rad51-like, C-terminal	DNA recombination and repair protein, RecA-like	DNA recombination and repair protein RecA-like, ATP-binding domain	DNA recombination and repair protein RecA, monomer-monomer interface	DNA recombination/repair protein Rad51	DNA repair Rad51/transcription factor NusA, alpha-helical	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q5TYR1 InterPro	340

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rad51-201 (1) Ensembl	Ensembl	1,547 nt	Select Tool
mRNA	rad51-202 (1) Ensembl	Ensembl	697 nt	Select Tool
mRNA	rad51-203 (1) Ensembl	Ensembl	524 nt	Select Tool
ncRNA	rad51-004 (1) Ensembl	Ensembl	384 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-rad51		rad51				Epitomics, Inc	1
Ab3-rad51	polyclonal	rad51		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations