Gene

rad51

ID
ZDB-GENE-040426-2286
Name
RAD51 recombinase
Symbol
rad51 Nomenclature History
Previous Names
  • wu:fb38e12
  • zgc:77754
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have DNA binding activity; DNA-dependent ATPase activity; and recombinase activity. Involved in several processes, including double-strand break repair via homologous recombination; hematopoietic stem cell proliferation; and response to methylmercury. Predicted to localize to condensed nuclear chromosome. Is expressed in brain; gill; liver; musculature system; and testis. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rad51 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance {Breast cancer, susceptibility to} 114480
Fanconi anemia complementation group R Alliance Fanconi anemia, complementation group R 617244
Mirror movements 2 614508
Associated With rad51 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003593 AAA+ ATPase domain
Domain IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
Domain IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
Domain IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
Domain IPR033925 Rad51/DMC1/RadA
Family IPR011941 DNA recombination/repair protein Rad51
Family IPR016467 DNA recombination and repair protein, RecA-like
Homologous_superfamily IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain DNA recombination and repair protein Rad51-like, C-terminal DNA recombination and repair protein, RecA-like DNA recombination and repair protein RecA-like, ATP-binding domain DNA recombination and repair protein RecA, monomer-monomer interface DNA recombination/repair protein Rad51 DNA repair Rad51/transcription factor NusA, alpha-helical P-loop containing nucleoside triphosphate hydrolase Rad51/DMC1/RadA
UniProtKB:Q6P5K8 338
UniProtKB:Q5TYR0 182
UniProtKB:Q5TYR2 44
UniProtKB:Q5TYR1 340
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rad51
Epitomics, Inc
1
Ab3-rad51 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations