Gene

rad51

ID
ZDB-GENE-040426-2286
Name
RAD51 recombinase
Symbol
rad51 Nomenclature History
Previous Names
  • wu:fb38e12
  • zgc:77754
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Is predicted to enable DNA binding activity and catalytic activity, acting on DNA. Involved in DNA recombination and chromosome organization involved in meiotic cell cycle. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; hematopoietic stem cell proliferation; and response to methylmercury. Predicted to be located in nucleus. Is expressed in brain; gill; liver; musculature system; and testis. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rad51 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance {Breast cancer, susceptibility to} 114480
Fanconi anemia complementation group R Alliance Fanconi anemia, complementation group R 617244
Mirror movements 2 614508
Associated With rad51 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003593 AAA+ ATPase domain
Domain IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
Domain IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
Domain IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
Domain IPR033925 Rad51/DMC1/RadA
Family IPR011941 DNA recombination/repair protein Rad51
Family IPR016467 DNA recombination and repair protein, RecA-like
Homologous_superfamily IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain DNA recombination and repair protein Rad51-like, C-terminal DNA recombination and repair protein, RecA-like DNA recombination and repair protein RecA-like, ATP-binding domain DNA recombination and repair protein RecA, monomer-monomer interface DNA recombination/repair protein Rad51 DNA repair Rad51/transcription factor NusA, alpha-helical P-loop containing nucleoside triphosphate hydrolase Rad51/DMC1/RadA
UniProtKB:Q5TYR0 182
UniProtKB:Q5TYR2 44
UniProtKB:Q5TYR1 340
UniProtKB:Q6P5K8 338
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rad51
Epitomics, Inc
1
Ab3-rad51 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations