Gene
tpm4a
- ID
- ZDB-GENE-040426-2185
- Name
- tropomyosin 4a
- Symbol
- tpm4a Nomenclature History
- Previous Names
-
- TPM4-1 (1)
- tpm4
- wu:fb06e07
- zgc:103436
- zgc:63909
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within cardiac muscle contraction and cardiac myofibril assembly. Predicted to be active in actin filament. Is expressed in several structures, including cardiovascular system; head mesenchyme; mesoderm; muscle; and thymus. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103436 (17 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tpm4a | N/A | Zhao et al., 2008 |
| MO2-tpm4a | N/A | Zhao et al., 2008 |
| MO3-tpm4a | N/A | Zhao et al., 2008 |
| MO4-tpm4a | N/A | Zhao et al., 2008 |
| MO5-tpm4a | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bleeding disorder, platelet-type, 25 | 620486 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
|---|---|---|---|---|
| UniProtKB:Q7T3F0 | InterPro | 248 | ||
| UniProtKB:F1R412 | InterPro | 284 | ||
| UniProtKB:Q5U3J6 | InterPro | 284 | ||
| UniProtKB:A0A8M6Z3C6 | InterPro | 248 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-69P9 | ZFIN Curated Data | |
| Encodes | EST | fb06e07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63909 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103436 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213158 (1) | 1804 nt | ||
| Genomic | GenBank:BX322595 (2) | 147460 nt | ||
| Polypeptide | UniProtKB:F1R412 (1) | 284 aa |
- Yang, S., Cao, S., Xu, X., Li, Q., Li, J., Guo, J., Wang, F., Bao, Y., Jiang, Z., Zhang, T., Wang, L., Sun, S. (2023) adducin 1 is essential for the survival of erythroid precursors via regulating p53 transcription in zebrafish. iScience. 26:107516107516
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Liu, L., Fei, F., Zhang, R., Wu, F., Yang, Q., Wang, F., Sun, S., Zhao, H., Li, Q., Wang, L., Wang, Y., Gui, Y., Wang, X. (2019) Combinatorial genetic replenishments in myocardial and outflow tract tissues restore heart function in tnnt2 mutant zebrafish. Biology Open. 8(12):
- Cai, C., Sang, C., Du, J., Jia, H., Tu, J., Wan, Q., Bao, B., Xie, S., Huang, Y., Li, A., Li, J., Yang, K., Wang, S., Lu, Q. (2018) Knockout of tnni1b in zebrafish causes defects in atrioventricular valve development via the inhibition of the myocardial wnt signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(1):696-710
- Segert, J., Schneider, I., Berger, I.M., Rottbauer, W., Just, S. (2018) Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish. Progress in Biophysics and Molecular Biology. 138:20-31
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Dube, D.K., Dube, S., Abbott, L., Wang, J., Fan, Y., Alshiekh-Nasany, R., Shah, K.K., Rudloff, A.P., Poiesz, B.J., Sanger, J.M., Sanger, J.W. (2017) Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish. Cytoskeleton (Hoboken, N.J.). 74(3):125-142
- Chen, W.C., Wang, Z., Missinato, M.A., Park, D.W., Long, D.W., Liu, H.J., Zeng, X., Yates, N.A., Kim, K., Wang, Y. (2016) Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Science advances. 2:e1600844
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