Gene
slc39a10
- ID
- ZDB-GENE-040426-1157
- Name
- solute carrier family 39 member 10
- Symbol
- slc39a10 Nomenclature History
- Previous Names
-
- ZIP10 (1)
- zgc:63552
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables zinc ion transmembrane transporter activity. Involved in epithelial to mesenchymal transition. Acts upstream of or within epiboly involved in gastrulation with mouth forming second; response to zinc ion; and zinc ion transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior axial hypoblast; hatching gland; kidney; pigment cell; and polster. Orthologous to human SLC39A10 (solute carrier family 39 member 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu363 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Taylor et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016533Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026840Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zju38 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc39a10 | He et al., 2023 | |
| MO1-slc39a10 | N/A | (2) |
| MO2-slc39a10 | N/A | (2) |
| MO3-slc39a10 | N/A | He et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc/iron permease | Zinc Iron Protein (ZIP) Transporter |
|---|---|---|---|
|
UniProtKB:A0A8M3AVY6
|
859 | ||
|
UniProtKB:Q6PEH9
|
847 | ||
|
UniProtKB:A0A0R4IJJ7
|
891 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc39a10-201
(1)
|
Ensembl | 5,196 nt | ||
| mRNA |
slc39a10-202
(1)
|
Ensembl | 5,763 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284H20 | ZFIN Curated Data | |
| Encodes | EST | eu363 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:63552 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200671 (1) | 3671 nt | ||
| Genomic | GenBank:CR936498 (2) | 111271 nt | ||
| Polypeptide | UniProtKB:A0A0R4IJJ7 (1) | 891 aa |
- He, X., Ge, C., Xia, J., Xia, Z., Zhao, L., Huang, S., Wang, R., Pan, J., Cheng, T., Xu, P.F., Wang, F., Min, J. (2023) The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 10(17):e2205345
- Puar, P., Naderi, M., Niyogi, S., Kwong, R.W.M. (2021) Using zebrafish as a model to assess the individual and combined effects of sub-lethal waterborne and dietary zinc exposure during development. Environmental pollution (Barking, Essex : 1987). 284:117377
- Kong, N., Zhao, Q., Liu, C., Li, J., Liu, Z., Gao, L., Wang, L., Song, L. (2020) The involvement of zinc transporters in the zinc accumulation in the Pacific oyster Crassostrea gigas. Gene. 750:144759
- Muraina, I.A., Maret, W., Bury, N.R., Hogstrand, C. (2020) Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a. Biochemical and Biophysical Research Communications. 528(4):698-705
- Puar, P., Niyogi, S., Kwong, R.W.M. (2020) Regulation of metal homeostasis and zinc transporters in early-life stage zebrafish following sublethal waterborne zinc exposure. Aquatic toxicology (Amsterdam, Netherlands). 225:105524
- Xia, Z., Bi, X., Lian, J., Dai, W., He, X., Zhao, L., Min, J., Wang, F. (2020) Slc39a5-mediated zinc homeostasis plays an essential role in venous angiogenesis in zebrafish. Open Biology. 10:200281
- Zhao, L., Tan, J., Li, D., Jiang, L., Li, T., Yang, Y., Wang, G., Shang, Z., Wang, J., Zhou, J. (2019) SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Biochemical and Biophysical Research Communications. 511(4):896-902
- Zhu, Q.L., Li, W.Y., Zheng, J.L. (2018) Life-cycle exposure to cadmium induced compensatory responses towards oxidative stress in the liver of female zebrafish. Chemosphere. 210:949-957
- Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS One. 12:e0183831
- Zheng, J.L., Guo, S.N., Yuan, S.S., Xia, H., Zhu, Q.L., Lv, Z.M. (2017) Preheating mitigates cadmium toxicity in zebrafish livers: Evidence from promoter demethylation, gene transcription to biochemical levels. Aquatic toxicology (Amsterdam, Netherlands). 190:104-111
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