Gene

traf4a

ID

ZDB-GENE-040308-1

Name

tnf receptor-associated factor 4a

Symbol

traf4a Nomenclature History

Previous Names

traf4l

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have tumor necrosis factor receptor binding activity and zinc ion binding activity. Predicted to be involved in protein K63-linked ubiquitination; regulation of intracellular signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to localize to cytoplasm. Is expressed in several structures, including axial blood vessel; digestive system; immature eye; mesoderm; and nervous system. Orthologous to human TRAF4 (TNF receptor associated factor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu286 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Hehr et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With traf4a Human Ortholog

No data available

Associated With traf4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001293	Zinc finger, TRAF-type
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR002083	MATH/TRAF domain
Domain	IPR018957	Zinc finger, C3HC4 RING-type
Domain	IPR037307	TNF receptor-associated factor 4, MATH domain
Domain	IPR049342	TRAF1-6, MATH domain
Family	IPR012227	TNF receptor-associated factor TRAF, metazoa
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type