Gene

ldb3a

ID

ZDB-GENE-040121-6

Name

LIM domain binding 3a

Symbol

ldb3a Nomenclature History

Previous Names

ldb3
cypher (1)
hm:zehn1639
zasp (1)
zehn1639

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have actin binding activity and muscle alpha-actinin binding activity. Involved in animal organ development; locomotory behavior; and somitogenesis. Predicted to localize to Z disc; actin cytoskeleton; and adherens junction. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Is expressed in several structures, including adaxial cell; intestine; musculature system; pericardial region; and sensory system. Orthologous to human LDB3 (LIM domain binding 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56098 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ldb3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1C	Alliance	Cardiomyopathy, dilated, 1C, with or without LVNC	601493
dilated cardiomyopathy 1C	Alliance	Cardiomyopathy, hypertrophic, 24	601493
dilated cardiomyopathy 1C	Alliance	Left ventricular noncompaction 3	601493
myofibrillar myopathy 4	Alliance	Myopathy, myofibrillar, 4	609452

Associated With ldb3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR001781	Zinc finger, LIM-type
Domain	IPR006643	Zasp-like motif
Domain	IPR031847	PDZ and LIM domain protein 1-4/Zasp-like, middle domain
Family	IPR050604	PDZ and LIM domain-containing
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	PDZ and LIM domain-containing	PDZ and LIM domain protein 1-4/Zasp-like, middle domain	PDZ domain	PDZ superfamily	Zasp-like motif	Zinc finger, LIM-type
UniProtKB:Q7ZVD3 InterPro	291
UniProtKB:A0A8M9Q9Y7 InterPro	746

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	ldb3a-211 (1) Ensembl	Ensembl	1,516 nt	Select Tool
mRNA	ldb3a-201 (1) Ensembl	Ensembl	852 nt	Select Tool
mRNA	ldb3a-202 (1) Ensembl	Ensembl	780 nt	Select Tool
mRNA	ldb3a-203 (1) Ensembl	Ensembl	900 nt	Select Tool
mRNA	ldb3a-204 (1) Ensembl	Ensembl	1,322 nt	Select Tool
mRNA	ldb3a-205 (1) Ensembl	Ensembl	4,619 nt	Select Tool
mRNA	ldb3a-206 (1) Ensembl	Ensembl	1,791 nt	Select Tool
mRNA	ldb3a-207 (1) Ensembl	Ensembl	2,191 nt	Select Tool ZFIN BLAST
mRNA	ldb3a-208 (1) Ensembl	Ensembl	777 nt	Select Tool
mRNA	ldb3a-209 (1) Ensembl	Ensembl	1,767 nt	Select Tool
mRNA	ldb3a-210 (1) Ensembl	Ensembl	791 nt	Select Tool
mRNA	ldb3a-212 (1) Ensembl	Ensembl	2,119 nt	Select Tool
mRNA	ldb3a-213 (1) Ensembl	Ensembl	856 nt	Select Tool
mRNA	ldb3a-214 (1) Ensembl	Ensembl	925 nt	Select Tool
mRNA	ldb3a-215 (1) Ensembl	Ensembl	911 nt	Select Tool
mRNA	ldb3a-216 (1) Ensembl	Ensembl	867 nt	Select Tool
mRNA	ldb3a-217 (1) Ensembl	Ensembl	880 nt	Select Tool
mRNA	ldb3a-218 (1) Ensembl	Ensembl	2,507 nt	Select Tool ZFIN BLAST
mRNA	ldb3a-219 (1) Ensembl	Ensembl	1,592 nt	Select Tool ZFIN BLAST
mRNA	ldb3a-220 (1) Ensembl	Ensembl	1,745 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations