Gene

foxi3b

ID

ZDB-GENE-031126-4

Name

forkhead box I3b

Symbol

foxi3b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within epidermal cell fate specification and ionocyte differentiation. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; integument; ionocyte; ionocyte progenitor cell; and yolk. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Orthologous to several human genes including FOXI1 (forkhead box I1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxi3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Craniofacial microsomia 2	620444

Associated With foxi3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018122	Fork head domain conserved site1
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Family	IPR050211	Forkhead box domain-containing protein
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily