Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-031118-121
Gene Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Gene Symbol: erbb2
Previous Names: wu:fv70f10, zgc:63601
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
  cranial ganglion, fin, lens, melanocyte (all 7) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 16 genotypes
Alleles: la012096Tg, la012097Tg, la012098Tg, la018007Tg, sa18607 (all 8) expand
Knockdown reagents: MO1-erbb2 (1), MO2-erbb2 (1)
PHENOTYPE
Data: 8 figures from 4 publications
Observed in: atrium, cardiac conduction, cardiac conduction system development, cardiac muscle cell (all 16) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Adenocarcinoma of lung, somatic 211980
Gastric cancer, somatic 613659
Glioblastoma, somatic 137800
Ovarian cancer, somatic,
GENE ONTOLOGY
Ontology GO Term
Biological Process Schwann cell development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 27)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000494 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR006211 (1)
  • InterPro:IPR006212 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR016245 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00757 (1)
  • Pfam:PF01030 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA erbb2-001 (1) 4093
    ncRNA erbb2-002 (1) 765
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-erbb2 (1)
    CONSTRUCTS WITH SEQUENCES FROM erbb2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    erbb2 Contained in: [BAC] DKEY-25P11 (1)
    erbb2 Has Artifact: [cDNA] WITHDRAWN:MGC:63601 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200119 (1) 3956 bp
    Genomic GenBank:CR457459 (1) 206901 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1R5S1 (1) 1275 aa
    Sequence Clusters UniGene:52559 (1)
    Sequence Information (all 11)
    OTHER erbb2 GENE PAGES
  • Gene:386966 (1)
  • VEGA:OTTDARG00000020518 (1)
  • Ensembl(Zv9):ENSDARG00000026294 (1)
  • MAPPING INFORMATION
    Chr: 12 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish erbb2 12  
    Human ERBB2 17 (17q12)
  • OMIM:164870
  • Gene:2064
  • CITATIONS (36)