ZFIN ID: ZDB-GENE-031118-121
Gene Name: erb-b2 receptor tyrosine kinase 2
Gene Symbol: erbb2
Previous Names: wu:fv70f10, zgc:63601
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
  cranial ganglion, fin, lens, melanocyte (all 7) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 20 Genotypes
Knockdown reagents: MO1-erbb2 (1), MO2-erbb2 (1)

Allele Type Mutagen Suppliers
la012096Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012097Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012098Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018007Tg Transgenic Insertion DNA
    sa18607 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • st50 Point Mutation
    st61 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t20604 Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 11 figures from 7 publications
    Observed in: atrium, cardiac conduction, cardiac conduction system development, cardiac muscle cell cell projection (all 25) expand
    DISEASE ASSOCIATED WITH erbb2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    lung cancer Adenocarcinoma of lung, somatic 211980
    stomach cancer Gastric cancer, somatic 613659
    malignant glioma Glioblastoma, somatic 137800
    Ovarian cancer, somatic,
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Schwann cell development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000494 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR006211 (1)
  • InterPro:IPR006212 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR016245 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00757 (1)
  • Pfam:PF01030 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA erbb2-001 (1) 4093
    ncRNA erbb2-002 (1) 765
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-erbb2 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM erbb2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    erbb2 Contained in: [BAC] DKEY-25P11 (1) (order this)
    erbb2 Has Artifact: [cDNA] WITHDRAWN:MGC:63601 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200119 (1) 3956 bp
    Genomic GenBank:CR457459 (1) 206901 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1R5S1 (1) 1275 aa
    Sequence Clusters UniGene:52559 (1)
    Sequence Information (all 11)
    OTHER erbb2 GENE PAGES
  • Gene:386966 (1)
  • VEGA:OTTDARG00000020518 (1)
  • Ensembl(Zv9):ENSDARG00000026294 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish erbb2 12  
    Human ERBB2 17 (17q12)
  • OMIM:164870
  • Gene:2064
  • Mouse Erbb2 11 ( 61.75 cM)
  • MGI:95410
  • Gene:13866
  • Orthology Details
    CITATIONS (44)