Gene

erbb2

ID
ZDB-GENE-031118-121
Name
erb-b2 receptor tyrosine kinase 2
Symbol
erbb2 Nomenclature History
Previous Names
  • wu:fv70f10
  • zgc:63601
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in animal organ development; fin regeneration; and nervous system development. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in several structures, including anterior segment eye; cranial ganglion; fin; heart; and primary neurons. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; malignant glioma; mammary Paget's disease; prostate cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With erbb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lung cancer Alliance Adenocarcinoma of lung, somatic 211980
stomach cancer Alliance Gastric cancer, somatic 613659
Glioblastoma, somatic 137800
Ovarian cancer, somatic
Associated With erbb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR032778 Growth factor receptor domain 4
Family IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Growth factor receptor domain 4 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine protein kinase, EGF/ERB/XmrK receptor
UniProtKB:F1R5S1 1275
UniProtKB:A0A0B5JQ80 645
UniProtKB:Q5EBY4 1275
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-erbb2 polyclonal IgG Rabbit
  • IHC
EMD Chemicals Inc., an Affiliate of Merck KGaA
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations