Gene

erbb4a

ID

ZDB-GENE-030918-4

Name

erb-b2 receptor tyrosine kinase 4a

Symbol

erbb4a Nomenclature History

Previous Names

erbb4
erbb4c (1)
si:ch211-227n20.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable epidermal growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within generation of neurons. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in heart and nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With erbb4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 19	Alliance	Amyotrophic lateral sclerosis 19	615515

Associated With erbb4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000494	Receptor L-domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR006211	Furin-like cysteine-rich domain
Domain	IPR032778	Growth factor receptor domain 4
Domain	IPR049328	Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment
Family	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036941	Receptor L-domain superfamily
Homologous_superfamily	IPR044912	Epidermal growth factor receptor, juxtamembrane domain
Repeat	IPR006212	Furin-like repeat

Domain Details Per Protein

Protein	Length	Epidermal growth factor receptor, juxtamembrane domain	Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment	Furin-like cysteine-rich domain	Furin-like repeat	Growth factor receptor cysteine-rich domain superfamily	Growth factor receptor domain 4	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Receptor L-domain	Receptor L-domain superfamily	Receptor Tyrosine Kinase	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine protein kinase, EGF/ERB/XmrK receptor
UniProtKB:B8LFF6 InterPro	1414

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	erbb4a-201 (1) Ensembl	Ensembl	4,470 nt	Select Tool ZFIN BLAST
mRNA	erbb4a-202 (1) Ensembl	Ensembl	3,890 nt	Select Tool ZFIN BLAST
mRNA	erbb4a-203 (1) Ensembl	Ensembl	3,643 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-erbb4	monoclonal	erbb4a	IgG	Rabbit	WB	Abcam plc	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations