ZFIN ID: ZDB-GENE-030918-4
Gene Name: erb-b2 receptor tyrosine kinase 4a
Gene Symbol: erbb4a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: erbb4, erbb4c (1), si:ch211-227n20.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have epidermal growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in generation of neurons. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in heart and optic tectum. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19 and colorectal cancer. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4).
Genome Resources: Alliance (1),  Gene:100007677 (1),  Ensembl(GRCz11):ENSDARG00000063207 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021329Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8456 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25516 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39540 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39541 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ubs35 Small Deletion Unknown Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-erbb4a 1
    MO1-erbb4a N/A 2
    MO2-erbb4a N/A 2
    MO3-erbb4a N/A 1
    DISEASE ASSOCIATED WITH erbb4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    amyotrophic lateral sclerosis type 19 Alliance Amyotrophic lateral sclerosis 19 615515
    DISEASE ASSOCIATED WITH erbb4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process generation of neurons (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA erbb4a-201 (1)    Ensembl 4470
    erbb4a-202 (1)    Ensembl 3890
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-erbb4 monoclonal IgG Rabbit WB Abcam plc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM erbb4a No data available
    MARKER RELATIONSHIPS
    erbb4a Contained in: [BAC] CH211-227N20 (1)
    erbb4a Contains: [STS] zfish-80h05.p1k (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001143751 (1) 4480 nt
    Genomic GenBank:BX927062 (1) 154186 nt
    Select Tool
    Polypeptide UniProtKB:B8LFF6 (1) 1414 aa
    Sequence Information (all 12)
    ORTHOLOGY for erbb4a ( Chr: 1 )
    CITATIONS (33)