Gene
fyna
- ID
- ZDB-GENE-030903-5
- Name
- FYN proto-oncogene, Src family tyrosine kinase a
- Symbol
- fyna Nomenclature History
- Previous Names
-
- fyn
- zgc:86720
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables protein kinase activity. Acts upstream of or within several processes, including adherens junction maintenance; gastrulation; and regulation of cytosolic calcium ion concentration. Located in cytosol and nucleus. Is expressed in central nervous system; olfactory placode; peripheral olfactory organ; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease; alcohol dependence; and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6897140 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu2570 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa14225 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36363 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36364 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42896 | Allele with one point mutation | Unknown | Missense, Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fyna | Charlton-Perkins et al., 2019 | |
| CRISPR2-fyna | Charlton-Perkins et al., 2019 | |
| MO1-fyna,fynb | N/A | (7) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035750 | Fyn/Yrk, SH3 domain |
| Domain | IPR047924 | Fyn/Yrk, SH2 domain |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fyn/Yrk, SH2 domain | Fyn/Yrk, SH3 domain | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6EWH2 | InterPro | 537 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(14xUAS:fyna_Y531F,Xla.Cryg:EGFP) |
|
| 2 | Siddiqui et al., 2024 | |
| Tg(mbpa:mCherry,cafyna) |
|
| 1 | (3) | |
| Tg(mbpa:mCherry,fyna) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266G18 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6897140 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86720 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328163 (1) | 3217 nt | ||
| Genomic | GenBank:CU306817 | 176617 nt | ||
| Polypeptide | UniProtKB:Q6EWH2 (1) | 537 aa |
- Siddiqui, S., Liu, F., Kanthasamy, A.G., McGrail, M. (2024) Stat3 mediates Fyn kinase-driven dopaminergic neurodegeneration and microglia activation. Disease models & mechanisms. 17(12):
- Vandestadt, C., Vanwalleghem, G.C., Khabooshan, M.A., Douek, A.M., Castillo, H.A., Li, M., Schulze, K., Don, E., Stamatis, S.A., Ratnadiwakara, M., Änkö, M.L., Scott, E.K., Kaslin, J. (2021) RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish. Developmental Cell. 56:2364-2380.e8
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L., Chávez, F.P. (2017) In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.. Frontiers in cellular and infection microbiology. 7:334
- Rauwerda, H., Pagano, J.F., de Leeuw, W.C., Ensink, W., Nehrdich, U., de Jong, M., Jonker, M., Spaink, H.P., Breit, T.M. (2017) Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos. BMC Genomics. 18:287
- Luo, Q., Wu, C., Sun, S., Lu, F., Xie, L., Zhao, H., Zhong, X., Zhou, Q. (2016) The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Journal of Fish Biology. 88(4):1584-97
- Sempou, E., Biasini, E., Pinzón-Olejua, A., Harris, D.A., Málaga-Trillo, E. (2016) Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo. Molecular neurodegeneration. 11:18
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Czopka, T., Ffrench-Constant, C., and Lyons, D.A. (2013) Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo. Developmental Cell. 25(6):599-609
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