Gene
uox
- ID
- ZDB-GENE-030826-24
- Name
- urate oxidase
- Symbol
- uox Nomenclature History
- Previous Names
-
- cb745 (1)
- wu:fd44h08
- zgc:92414
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables urate oxidase activity. Involved in urate catabolic process. Acts upstream of or within protein homotetramerization and urate metabolic process. Predicted to be active in peroxisome. Is expressed in head; hepatocyte; horizontal myoseptum; liver; and periderm. Used to study gout. Orthologous to human UOX (urate oxidase (pseudogene)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb745 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Linnerz et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-uox | Zebrafish Nomenclature Committee | |
| CRISPR2-uox | Linnerz et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Urate oxidase deficiency] |
1 - 1 of 1
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| gout | uoxnz56/nz56 | standard conditions | Linnerz et al., 2022 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR002042 | Uricase |
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Domain Details Per Protein
| Protein | Length | Uricase |
|---|---|---|
|
UniProtKB:Q6DG85
|
298 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-213O6 | ZFIN Curated Data | |
| Contains | STS | chunp30158 | ||
| Encodes | EST | cb745 | Thisse et al., 2001 | |
| Encodes | EST | fd44h08 | ||
| Encodes | cDNA | MGC:92414 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191236 | ZFIN Curated Data | |
| Has Artifact | EST | fb63e04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002332 (1) | 1010 nt | ||
| Genomic | GenBank:CR931978 (1) | 153616 nt | ||
| Polypeptide | UniProtKB:Q6DG85 (1) | 298 aa |
- Xiao, Y., Miao, Z., Sun, J., Xing, W., Wei, Y., Bai, J., Ye, H., Si, Y., Cai, L. (2023) Allisartan Isoproxil Promotes Uric Acid Excretion by Interacting with Intestinal Urate Transporters in Hyperuricemic Zebrafish (Danio rerio). Bulletin of experimental biology and medicine. 175(5):638-643
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Linnerz, T., Sung, Y.J., Rolland, L., Astin, J.W., Dalbeth, N., Hall, C.J. (2022) Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence. Genes. 13(12):
- Hu, L., Li, H., Chi, Z., He, J. (2020) Loss of the RNA-binding protein Rbm15 disrupts liver maturation in zebrafish. The Journal of biological chemistry. 295(33):11466-11472
- Wang, F., Liu, F., Chen, W. (2018) Exposure to triclosan changes the expression of microRNA in male juvenile zebrafish (Danio rerio). Chemosphere. 214:651-658
- Zhang, Y., Li, Q., Wang, F., Xing, C. (2018) A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity. Biochemical and Biophysical Research Communications. 508(2):494-498
- Hurem, S., Martín, L.M., Lindeman, L., Brede, D.A., Salbu, B., Lyche, J.L., Aleström, P., Kamstra, J.H. (2017) Parental exposure to gamma radiation causes progressively altered transcriptomes linked to adverse effects in zebrafish offspring. Environmental pollution (Barking, Essex : 1987). 234:855-863
- Ronda, L., Marchetti, M., Piano, R., Liuzzi, A., Corsini, R., Percudani, R., Bettati, S. (2017) A Trivalent Enzymatic System for Uricolytic Therapy of HPRT Deficiency and Lesch-Nyhan Disease. Pharmaceutical research. 34(7):1477-1490
- Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770
- Marchetti, M., Liuzzi, A., Fermi, B., Corsini, R., Folli, C., Speranzini, V., Gandolfi, F., Bettati, S., Ronda, L., Cendron, L., Berni, R., Zanotti, G., Percudani, R. (2016) Catalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in Hominoids. Scientific Reports. 6:38302
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