Gene
ptf1a
- ID
- ZDB-GENE-030616-579
- Name
- pancreas associated transcription factor 1a
- Symbol
- ptf1a Nomenclature History
- Previous Names
-
- Ptfa (1)
- si:zc142h2.2
- zgc:112216
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in animal organ development and positive regulation of transcription, DNA-templated. Predicted to localize to cytoplasm; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in pancreatic agenesis. Is expressed in several structures, including central nervous system; exocrine cell; eye; mid intestine; and pancreatic system. Orthologous to human PTF1A (pancreas associated transcription factor 1a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 79 figures from 51 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu536 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pancreatic agenesis 2 | Alliance | Pancreatic agenesis 2 | 615935 |
| Pancreatic and cerebellar agenesis | 609069 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:Q7ZSX3
|
265 |
Interactions and Pathways
No data available
Plasmids
No data available