Gene
ptenb
- ID
- ZDB-GENE-030616-47
- Name
- phosphatase and tensin homolog B
- Symbol
- ptenb Nomenclature History
- Previous Names
-
- pten
- fa11a08
- fb73f10
- fc83f12
- fd16b10
- fk90e11
- si:bz1g13.4
- wu:fa11a08
- wu:fb73f10
- wu:fc83f12
- wu:fd16b10
- wu:fk90e11
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic density. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including adaxial cell; blastomere; nervous system; neural rod; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7163207 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu1435 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la018072Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018073Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17852 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44756 | Allele with one point mutation | Unknown | Unknown | ENU | |
| zf3644 | unknown | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ptenb | (4) | |
| CRISPR2-ptenb | Luo et al., 2021 | |
| CRISPR3-ptenb | Suresh et al., 2022 | |
| MO1-ptenb | N/A | (4) |
| MO2-ptenb | N/A | (2) |
| MO3-ptenb | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bannayan-Riley-Ruvalcaba syndrome | Alliance | Cowden syndrome 1 | 158350 |
| Bannayan-Riley-Ruvalcaba syndrome | Alliance | Lhermitte-Duclos disease | 158350 |
| macrocephaly-autism syndrome | Alliance | Macrocephaly/autism syndrome | 605309 |
| prostate cancer | Alliance | Prostate cancer, somatic | 176807 |
| {Glioma susceptibility 2} | 613028 | ||
| {Meningioma} | 607174 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR014020 | Tensin phosphatase, C2 domain |
| Domain | IPR029023 | Tensin-type phosphatase domain |
| Domain | IPR045101 | PTEN, phosphatase domain |
| Family | IPR017361 | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN |
| Family | IPR051281 | Dual-specificity lipid and protein phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN | C2 domain superfamily | Dual-specificity lipid and protein phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | PTEN, phosphatase domain | Tensin phosphatase, C2 domain | Tensin-type phosphatase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZZ56 | InterPro | 399 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-1G13 | ZFIN Curated Data | |
| Encodes | EST | fa11a08 | ||
| Encodes | EST | fb73f10 | ||
| Encodes | EST | fc83f12 | ||
| Encodes | EST | fd16b10 | ||
| Encodes | EST | fk90e11 | ||
| Encodes | EST | IMAGE:7163207 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:123112 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423688 (1) | 5240 nt | ||
| Genomic | GenBank:AL731788 (2) | 165909 nt | ||
| Polypeptide | UniProtKB:Q7ZZ56 (1) | 399 aa |
- Lumaquin-Yin, D., Montal, E., Johns, E., Baggiolini, A., Huang, T.H., Ma, Y., LaPlante, C., Suresh, S., Studer, L., White, R.M. (2023) Lipid droplets are a metabolic vulnerability in melanoma. Nature communications. 14:31923192
- Tagore, M., Hergenreder, E., Perlee, S.C., Cruz, N.M., Menocal, L., Suresh, S., Chan, E., Baron, M., Melendez, S., Dave, A., Chatila, W.K., Nsengimana, J., Koche, R.P., Hollmann, T.J., Ideker, T., Studer, L., Schietinger, A., White, R.M. (2023) GABA regulates electrical activity and tumor initiation in melanoma. Cancer discovery. 13(10):2270-2291
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Suresh, S., Rabbie, R., Garg, M., Lumaquin, D., Huang, T.H., Montal, E., Ma, Y., Cruz, N.M., Tang, X., Nsengimana, J., Newton-Bishop, J., Hunter, M.V., Zhu, Y., Chen, K., de Stanchina, E., Adams, D.J., White, R.M. (2022) Identifying the transcriptional drivers of metastasis embedded within localized melanoma. Cancer discovery. 13(1):194-215
- Baggiolini, A., Callahan, S.J., Montal, E., Weiss, J.M., Trieu, T., Tagore, M.M., Tischfield, S.E., Walsh, R.M., Suresh, S., Fan, Y., Campbell, N.R., Perlee, S.C., Saurat, N., Hunter, M.V., Simon-Vermot, T., Huang, T.H., Ma, Y., Hollmann, T., Tickoo, S.K., Taylor, B.S., Khurana, E., Koche, R.P., Studer, L., White, R.M. (2021) Developmental chromatin programs determine oncogenic competence in melanoma. Science (New York, N.Y.). 373:eabc1048
- Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S., den Hertog, J. (2021) Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells. Oncogene. 40(15):2741-2755
- He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729
- Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers. 13(5):
- Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):
- Luo, J., Lu, C., Feng, M., Dai, L., Wang, M., Qiu, Y., Zheng, H., Liu, Y., Li, L., Tang, B., Xu, C., Wang, Y., Yang, X. (2021) Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. Journal of experimental & clinical cancer research : CR. 40:262
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