Gene
mc2r
- ID
- ZDB-GENE-030502-2
- Name
- melanocortin 2 receptor
- Symbol
- mc2r Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables corticotropin receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; adrenal gland development; and multicellular organismal response to stress. Located in cytoplasm and plasma membrane. Is expressed in adipose tissue; integument; pleuroperitoneal region; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mn57 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | TALEN | |
| mn58 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | TALEN | |
| mn59 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| mn60 | Allele with one deletion | Unknown | Unknown | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glucocorticoid deficiency 1 | Alliance | Glucocorticoid deficiency, due to ACTH unresponsiveness | 202200 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Melanocortin/ACTH receptor | Melanocortin receptor 3-5 |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZTA2
|
304 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181C1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_180971 (1) | 915 nt | ||
| Genomic | GenBank:CR848742 (1) | 177769 nt | ||
| Polypeptide | UniProtKB:Q7ZTA2 (1) | 304 aa |
- Arab-Bafrani, Z., Zabihi, E., Hoseini, S.M., Sepehri, H., Khalili, M. (2022) Silver nanoparticles modify hypothalamic-pituitary-interrenal axis and block cortisol response to an acute stress in zebrafish, Danio rerio. Toxicology and industrial health. 38(4):201-209
- Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):
- Kowatschew, D., Korsching, S.I. (2021) An ancient adenosine receptor gains olfactory function in bony vertebrates. Genome biology and evolution. 13(9)
- Mikloska, K.V., Zrini, Z.A., Bernier, N.J. (2021) Severe hypoxia exposure inhibits larval brain development but does not affect the capacity to mount a cortisol stress response in zebrafish. The Journal of experimental biology. 225(2)
- Ren, Q., Gao, D., Mou, L., Zhang, S., Zhang, M., Li, N., Sik, A., Jin, M., Liu, K. (2021) Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European Journal of Pharmacology. 912:174589
- Wang, L., Lin, W., Zha, Q., Guo, H., Zhang, D., Yang, L., Li, L., Li, D., Tang, R. (2020) Persistent Exposure to Environmental Levels of Microcystin-LR Disturbs Cortisol Production via Hypothalamic-Pituitary-Interrenal (HPI) Axis and Subsequently Liver Glucose Metabolism in Adult Male Zebrafish (Danio rerio). toxins. 12(5):
- Wei, P., Zhao, F., Zhang, X., Ru, S. (2020) Long-term exposure of zebrafish to bisphenol S impairs stress function of hypothalamic-pituitary-interrenal axis and causes anxiety-like behavioral responses to novelty. The Science of the total environment. 716:137092
- Shainer, I., Michel, M., Marquart, G.D., Bhandiwad, A.A., Zmora, N., Ben-Moshe Livne, Z., Zohar, Y., Hazak, A., Mazon, Y., Förster, D., Hollander-Cohen, L., Cone, R.D., Burgess, H.A., Gothilf, Y. (2019) Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. Current biology : CB. 29(12):2009-2019.e7
- Vera-Chang, M.N., Moon, T.W., Trudeau, V.L. (2019) Cortisol disruption and transgenerational alterations in the expression of stress-related genes in zebrafish larvae following fluoxetine exposure. Toxicology and applied pharmacology. 382:114742
- Chen, L., Wang, Y., Giesy, J.P., Chen, F., Shi, T., Chen, J., Xie, P. (2018) Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish. Environmental pollution (Barking, Essex : 1987). 241:540-548
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