Gene
hells
- ID
- ZDB-GENE-030131-9923
- Name
- helicase, lymphoid specific
- Symbol
- hells Nomenclature History
- Previous Names
-
- cb65 (1)
- im:6911667
- sb:cb65
- sb:cb749
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Acts upstream of or within regulation of DNA methylation. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; margin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb65 (7 images)
- cb749 (18 images)
- IMAGE:6911667 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Dunican et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency-centromeric instability-facial anomalies syndrome 4 | Alliance | Immunodeficiency-centromeric instability-facial anomalies syndrome 4 | 616911 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR044753 | HELLS, N-terminal |
| Domain | IPR049730 | SNF2/RAD5-like, C-terminal helicase domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | HELLS, N-terminal | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q3BDS6
|
853 |
Interactions and Pathways
No data available
Plasmids
No data available