Gene

tbc1d4

ID

ZDB-GENE-030131-9881

Name

TBC1 domain family, member 4

Symbol

tbc1d4 Nomenclature History

Previous Names

cb53 (1)
sb:cb53
si:ch211-222g23.4

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have GTPase activator activity and Rab GTPase binding activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Human ortholog(s) of this gene implicated in acanthosis nigricans. Is expressed in myotome; pancreatic bud; pronephric duct; and segmental plate. Orthologous to human TBC1D4 (TBC1 domain family member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2001

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb53 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbc1d4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Diabetes mellitus, noninsulin-dependent, 5}	616087

Associated With tbc1d4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000195	Rab-GAP-TBC domain
Domain	IPR006020	PTB/PI domain
Domain	IPR021785	Domain of unknown function DUF3350
Family	IPR050302	Rab GTPase-activating TBC domain-containing protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035969	Rab-GAP-TBC domain superfamily

Domain Details Per Protein

Protein	Length	Domain of unknown function DUF3350	PH-like domain superfamily	PTB/PI domain	Rab-GAP-TBC domain	Rab-GAP-TBC domain superfamily	Rab GTPase-activating TBC domain-containing protein
UniProtKB:A0A8M3B5R8 InterPro	1195
UniProtKB:A0A8M2BF73 InterPro	1247
UniProtKB:A0A8M2BF88 InterPro	1246
UniProtKB:A0A8M9QG34 InterPro	514
UniProtKB:A0A8M2BF77 InterPro	1196
UniProtKB:A0A8M1RM25 InterPro	1246

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tbc1d4-201 (1) Ensembl	Ensembl	4,019 nt	Select Tool
mRNA	tbc1d4-202 (1) Ensembl	Ensembl	756 nt	Select Tool
mRNA	tbc1d4-203 (1) Ensembl	Ensembl	3,186 nt	Select Tool ZFIN BLAST
mRNA	tbc1d4-204 (1) Ensembl	Ensembl	3,081 nt	Select Tool ZFIN BLAST
mRNA	tbc1d4-205 (1) Ensembl	Ensembl	877 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations