Gene
mmp2
- ID
- ZDB-GENE-030131-9123
- Name
- matrix metallopeptidase 2
- Symbol
- mmp2 Nomenclature History
- Previous Names
-
- Gelatinase A (1)
- wu:fa99h12
- wu:fk89d01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Involved in hematopoietic stem cell migration; lymph vessel development; and retinal ganglion cell axon guidance. Predicted to localize to extracellular matrix. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); ischemia; pseudoxanthoma elasticum; and temporal arteritis. Is expressed in several structures, including digestive system; nervous system; ovarian follicle; trunk; and vasculature. Orthologous to human MMP2 (matrix metallopeptidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 59 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136035 (1 image)
- IMAGE:7163203 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Multicentric osteolysis, nodulosis, and arthropathy | 259600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021158 | Peptidase M10A, cysteine switch, zinc binding site |
| Domain | IPR000562 | Fibronectin type II domain |
| Domain | IPR000585 | Hemopexin-like domain |
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Fibronectin type II domain | Fibronectin type II domain superfamily | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Kringle-like fold | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SZM5
|
657 |
Interactions and Pathways
No data available
Plasmids
No data available