header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-9123
Gene Name: matrix metallopeptidase 2
Gene Symbol: mmp2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: Gelatinase A (1), wu:fa99h12, wu:fk89d01

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Involved in hematopoietic stem cell migration; lymph vessel development; and retinal ganglion cell axon guidance. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); ischemia; pseudoxanthoma elasticum; and temporal arteritis. Is expressed in several structures, including digestive system; nervous system; ovarian follicle; trunk; and vasculature. Orthologous to human MMP2 (matrix metallopeptidase 2).
Genome Resources: Alliance (1),  Gene:337179 (1),  Ensembl(GRCz11):ENSDARG00000017676 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu10535 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa1218 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21006 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34122 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45285 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mmp2
    2
    CRISPR2-mmp2
    2
    CRISPR3-mmp2
    2
    CRISPR4-mmp2
    2
    CRISPR5-mmp2
    1
    CRISPR6-mmp2
    1
    MO1-mmp2 N/A 2
    MO2-mmp2 N/A 1
    MO3-mmp2 N/A 2
    TALEN1-mmp2 1
    DISEASE ASSOCIATED WITH mmp2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Multicentric osteolysis, nodulosis, and arthropathy 259600
    DISEASE ASSOCIATED WITH mmp2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process retinal ganglion cell axon guidance (more)
    Cellular Component extracellular matrix (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mmp2-201 (1)    Ensembl 3033
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:SS-HA-ATTB-1-mmp2_E404A-ATTB2-EGFP) hsp70l ATTBEGFPHAmmp2 Danio rerio 1 1
    MARKER RELATIONSHIPS
    mmp2 Contained in: [BAC] DKEY-182H7 (1) (order this)
    mmp2 Encodes: [EST] fa99h12 (1), fk89d01, IMAGE:7136035 (1) (order this), IMAGE:7163203 (1) (order this)
    [cDNA] MGC:92438 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198067 (1) 2966 bp
    Genomic GenBank:BX663609 (1) 248960 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q6DG10 (1) 657 aa
    Sequence Clusters UniGene:76397 (1)
    Sequence Information (all 19)
    ORTHOLOGY for mmp2 ( Chr: 7 )
    CITATIONS (106)