Gene

mmp2

ID
ZDB-GENE-030131-9123
Name
matrix metallopeptidase 2
Symbol
mmp2 Nomenclature History
Previous Names
  • Gelatinase A (1)
  • wu:fa99h12
  • wu:fk89d01
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Involved in several processes, including hematopoietic stem cell migration; lymph vessel development; and neurogenesis. Predicted to localize to extracellular matrix. Is expressed in several structures, including digestive system; nervous system; ovarian follicle; trunk musculature; and vasculature. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).
Genome Resources
Note
None
Expression
All Expression Data
44 figures from 29 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mmp2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Multicentric osteolysis, nodulosis, and arthropathy 259600
Associated With mmp2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
Domain IPR000562 Fibronectin type II domain
Domain IPR000585 Hemopexin-like domain
Domain IPR001818 Peptidase M10, metallopeptidase
Domain IPR002477 Peptidoglycan binding-like
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR033739 Peptidase M10A, catalytic domain
Family IPR021190 Peptidase M10A
Family IPR028708 72kDa type IV collagenase
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036365 PGBD-like superfamily
Homologous_superfamily IPR036366 PGBD superfamily
Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
Homologous_superfamily IPR036943 Fibronectin type II domain superfamily
Repeat IPR018487 Hemopexin-like repeats
Domain Details Per Protein
Protein Length 72kDa type IV collagenase Fibronectin type II domain Fibronectin type II domain superfamily Hemopexin-like domain Hemopexin-like domain superfamily Hemopexin-like repeats Kringle-like fold Metallopeptidase, catalytic domain superfamily Peptidase M10A Peptidase M10A, catalytic domain Peptidase M10A, cysteine switch, zinc binding site Peptidase M10, metallopeptidase Peptidase, metallopeptidase Peptidoglycan binding-like PGBD-like superfamily PGBD superfamily
UniProtKB:Q6DG10 657
UniProtKB:Q7SZM5 657
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mmp2 polyclonal IgG Rabbit
  • IHC
AnaSpec
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations