Gene
sdhb
- ID
- ZDB-GENE-030131-8005
- Name
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
- Symbol
- sdhb Nomenclature History
- Previous Names
-
- fj46d06
- wu:fj46d06
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable iron-sulfur cluster binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Acts upstream of or within mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrial membrane. Is expressed in several structures, including alar plate midbrain region; brain; eye; pronephric duct; and segmental plate. Used to study paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6896418 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| rmc200 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Carney-Stratakis syndrome | Alliance | Paraganglioma and gastric stromal sarcoma | 606864 |
| gastrointestinal stromal tumor | Alliance | Gastrointestinal stromal tumor | 606764 |
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 4 | 115310 |
| Mitochondrial complex II deficiency, nuclear type 4 | 619224 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| paraganglioma | sdhbrmc200/rmc200 (AB) | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR006058 | 2Fe-2S ferredoxin, iron-sulphur binding site |
| Conserved_site | IPR017900 | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| Domain | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Domain | IPR017896 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| Domain | IPR025192 | Succinate dehydogenase/fumarate reductase N-terminal |
| Family | IPR004489 | Succinate dehydrogenase/fumarate reductase iron-sulphur protein |
| Family | IPR050573 | Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur |
| Homologous_superfamily | IPR009051 | Alpha-helical ferredoxin |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 2Fe-2S ferredoxin, iron-sulphur binding site | 2Fe-2S ferredoxin-like superfamily | 2Fe-2S ferredoxin-type iron-sulfur binding domain | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Alpha-helical ferredoxin | Beta-grasp domain superfamily | Succinate dehydogenase/fumarate reductase N-terminal | Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur | Succinate dehydrogenase/fumarate reductase iron-sulphur protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A5PL98 | InterPro | 280 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-sdhb | monoclonal | IgG2a , k | Mouse |
|
MitoSciences
Abcam plc |
7 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | fj46d06 | ||
| Encodes | EST | IMAGE:6896418 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:165456 | ZFIN Curated Data |
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- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Miltenburg, J.B., Gorissen, M., van Outersterp, I., Versteeg, I., Nowak, A., Rodenburg, R.J., van Herwaarden, A.E., Olthaar, A.J., Kusters, B., Conrad, C., Timmers, H.J.L.M., Dona, M. (2024) Characterisation of an Adult Zebrafish Model for SDHB-Associated Phaeochromocytomas and Paragangliomas. International Journal of Molecular Sciences. 25(13):
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Xu, S.S., Li, Y., Wang, H.P., Chen, W.B., Wang, Y.Q., Song, Z.W., Liu, H., Zhong, S., Sun, Y.H. (2023) Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Zoological research. 44:63-77
- Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J. (2022) Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental Toxicology and Pharmacology. 93:103873
- Di, S., Wang, Z., Cang, T., Xie, Y., Zhao, H., Qi, P., Wang, X., Xu, H., Wang, X. (2021) Enantioselective toxicity and mechanism of chiral fungicide penflufen based on experiments and computational chemistry. Ecotoxicology and environmental safety. 222:112534
- Dona, M., Lamers, M., Rohde, S., Gorissen, M., Timmers, H.J.L.M. (2021) Targeting the Redox Balance Pathway Using Ascorbic Acid in sdhb Zebrafish Mutant Larvae. Cancers. 13(20):
- Li, X.Y., Qin, Y.J., Wang, Y., Huang, T., Zhao, Y.H., Wang, X.H., Martyniuk, C.J., Yan, B. (2021) Relative comparison of strobilurin fungicides at environmental levels: Focus on mitochondrial function and larval activity in early staged zebrafish (Danio rerio). Toxicology. 452:152706
- Wu, S., Chen, K., Xu, T., Ma, K., Gao, L., Fu, C., Zhang, W., Jing, C., Ren, C., Deng, M., Chen, Y., Zhou, Y., Pan, W., Jia, X. (2021) Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Frontiers in cell and developmental biology. 9:709923
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