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Gene

sdhb

ID
ZDB-GENE-030131-8005
Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Symbol
sdhb Nomenclature History
Previous Names
  • fj46d06
  • wu:fj46d06
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable iron-sulfur cluster binding activity and ubiquinone binding activity. Predicted to be involved in aerobic respiration and respiratory electron transport chain. Predicted to act upstream of or within tricarboxylic acid cycle. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Predicted to be active in mitochondrial membrane. Is expressed in several structures, including alar plate midbrain region; immature eye; optic tectum; pronephric duct; and segmental plate. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sdhb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Carney-Stratakis syndrome Alliance Paraganglioma and gastric stromal sarcoma 606864
gastrointestinal stromal tumor Alliance Gastrointestinal stromal tumor 606764
paraganglioma Alliance Paragangliomas 4 115310
pheochromocytoma Alliance Pheochromocytoma 171300
Mitochondrial complex II deficiency, nuclear type 4 619224
Associated With sdhb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
Conserved_site IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Domain IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
Domain IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Domain IPR025192 Succinate dehydogenase/fumarate reductase N-terminal
Family IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein
Homologous_superfamily IPR009051 Alpha-helical ferredoxin
Homologous_superfamily IPR012675 Beta-grasp domain superfamily
Homologous_superfamily IPR036010 2Fe-2S ferredoxin-like superfamily
Domain Details Per Protein
Protein Length 2Fe-2S ferredoxin, iron-sulphur binding site 2Fe-2S ferredoxin-like superfamily 2Fe-2S ferredoxin-type iron-sulfur binding domain 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 4Fe-4S ferredoxin-type, iron-sulphur binding domain Alpha-helical ferredoxin Beta-grasp domain superfamily Succinate dehydogenase/fumarate reductase N-terminal Succinate dehydrogenase/fumarate reductase iron-sulphur protein
UniProtKB:A5PL98 280
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB1-sdhb monoclonal IgG2a , k Mouse
  • IHC
  • WB
Abcam plc
MitoSciences
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations