Gene
rpn2
- ID
- ZDB-GENE-030131-7928
- Name
- ribophorin II
- Symbol
- rpn2 Nomenclature History
- Previous Names
-
- fb95d11
- fj62b10
- wu:fb61f08 (1)
- wu:fb74e07
- wu:fb95d11
- wu:fj41f11
- wu:fj62b10
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in female organism. Orthologous to human RPN2 (ribophorin II).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi3583Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la010031Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017695Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008814 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 |
|---|---|---|---|
| UniProtKB:Q7ZV07 | InterPro | 630 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rpn2-201
(1)
|
Ensembl | 1,936 nt | ||
| mRNA |
rpn2-202
(1)
|
Ensembl | 1,969 nt | ||
| mRNA |
rpn2-204
(1)
|
Ensembl | 722 nt | ||
| mRNA |
rpn2-205
(1)
|
Ensembl | 783 nt | ||
| mRNA |
rpn2-206
(1)
|
Ensembl | 537 nt | ||
| mRNA |
rpn2-207
(1)
|
Ensembl | 839 nt | ||
| mRNA |
rpn2-208
(1)
|
Ensembl | 2,286 nt | ||
| mRNA |
rpn2-209
(1)
|
Ensembl | 2,404 nt | ||
| ncRNA |
rpn2-006
(1)
|
Ensembl | 856 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-223I23 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-287G6 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-1403H8 | ZFIN Curated Data | |
| Encodes | EST | fb61f08 | ||
| Encodes | EST | fb74e07 | ||
| Encodes | EST | fb95d11 | ||
| Encodes | EST | fj41f11 | ||
| Encodes | EST | fj62b10 | ||
| Encodes | EST | IMAGE:6908674 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56291 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212748 (1) | 2381 nt | ||
| Genomic | GenBank:CU929092 (1) | 88958 nt | ||
| Polypeptide | UniProtKB:Q7ZV07 (1) | 630 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | RPN2 | 20 | Amino acid sequence comparison (1) |
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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