Gene
sod2
- ID
- ZDB-GENE-030131-7742
- Name
- superoxide dismutase 2, mitochondrial
- Symbol
- sod2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables superoxide dismutase activity. Acts upstream of or within several processes, including neutrophil homeostasis; removal of superoxide radicals; and response to methylmercury. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; hematopoietic cell; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 43 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb463 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sod2 | Zhou et al., 2018 | |
| CRISPR2-sod2 | Zhou et al., 2018 | |
| CRISPR3-sod2 | Rosello et al., 2021 | |
| MO1-sod2 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Microvascular complications of diabetes 6} | 612634 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR019833 | Manganese/iron superoxide dismutase, binding site |
| Domain | IPR019831 | Manganese/iron superoxide dismutase, N-terminal |
| Domain | IPR019832 | Manganese/iron superoxide dismutase, C-terminal |
| Family | IPR001189 | Manganese/iron superoxide dismutase |
| Family | IPR050265 | Iron/Manganese Superoxide Dismutase |
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Domain Details Per Protein
| Protein | Length | Iron/Manganese Superoxide Dismutase | Manganese/iron superoxide dismutase | Manganese/iron superoxide dismutase, binding site | Manganese/iron superoxide dismutase, C-terminal | Manganese/iron superoxide dismutase, C-terminal domain superfamily | Manganese/iron superoxide dismutase, N-terminal | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P980
|
224 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195E3 | ZFIN Curated Data | |
| Encodes | EST | cb463 | Thisse et al., 2001 | |
| Encodes | EST | fj33b01 | ||
| Encodes | cDNA | MGC:73051 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199976 (1) | 979 nt | ||
| Genomic | GenBank:AL929182 (1) | 225515 nt | ||
| Polypeptide | UniProtKB:Q6P980 (1) | 224 aa |
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Ulhaq, Z.S., Tse, W.K.F. (2024) Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1870(4):167128
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Wang, Y., Yuan, B., Liu, W., Cui, J., Zhou, X., Yuan, L., Deng, Z., Li, Y., Yuan, X. (2024) The Xaliproden Nanoscale Zirconium-Porphyrin Metal-Organic Framework (XAL-NPMOF) Promotes Photoreceptor Regeneration Following Oxidative and Inflammatory Insults. International Journal of Nanomedicine. 19:103871040010387-10400
- Xia, Z., Tang, B., Li, X., Li, X., Jia, Y., Jiang, J., Chen, J., Song, J., Liu, S., Min, J., Wang, F. (2024) A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese Transporter. Research (Washington, D.C.). 7:04400440
- Zhong, X., Zhang, G., Huang, J., Chen, L., Shi, Y., Wang, D., Zheng, Q., Su, H., Li, X., Wang, C., Zhang, J., Guo, L. (2024) Effects of Intestinal Microbiota on the Biological Transformation of Arsenic in Zebrafish: Contribution and Mechanism. Environmental science & technology. 58(5):2247-2259
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Qin, M.C., Li, J.J., Zheng, Y.T., Li, Y.J., Zhang, Y.X., Ou, R.X., He, W.Y., Zhao, J.M., Liu, S.T., Liu, M.H., Lin, H.Y., Gao, L. (2023) Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration. Food & function. 14(23):10347-10361
- Ravindra, J., Ug, Y., Pandyanda Nanjappa, D., Kalladka, K., Dhakal, R., Chakraborty, A., Chakraborty, G. (2023) Allicin extracted from Allium sativum shows potent anti-cancer and antioxidant properties in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 169:115854115854
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