Gene
tep1
- ID
- ZDB-GENE-030131-6153
- Name
- telomerase-associated protein 1
- Symbol
- tep1 Nomenclature History
- Previous Names
-
- si:ch211-284o19.1
- si:rp71-1g18.6
- wu:fb19f02
- wu:fi36h03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable telomerase RNA binding activity. Predicted to contribute to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Predicted to be part of telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and stomach cancer. Orthologous to human TEP1 (telomerase associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150837 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6856 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32973 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32974 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38344 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | APAF-1 helical domain | Domain of unknown function DUF4062 | Domain of unknown function DUF5920 | NACHT nucleoside triphosphatase | P-loop containing nucleoside triphosphate hydrolase | Quinoprotein alcohol dehydrogenase-like superfamily | Telomerase Complex Component | TROVE domain | TROVE domain superfamily | von Willebrand factor A-like domain superfamily | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AXG0
|
2677 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284O19 | ZFIN Curated Data | |
| Contained in | BAC | RP71-1G18 | ||
| Contains | SNP | rs3727645 | ZFIN Curated Data | |
| Contains | SNP | rs3727646 | ZFIN Curated Data | |
| Contains | SNP | rs3727647 | ZFIN Curated Data | |
| Encodes | EST | fb19f02 | ZFIN Curated Data | |
| Encodes | EST | fi36h03 | ||
| Encodes | EST | IMAGE:7150837 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009298675 (1) | 8247 nt | ||
| Genomic | GenBank:AL627248 (1) | 143586 nt | ||
| Polypeptide | UniProtKB:A0A8M3AXG0 (1) | 2677 aa |
- Comparative Orthology
- Alliance
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ju, Z., Wells, M.C., Martinez, A., Hazlewood, L., and Walter, R.B. (2005) An in silico mining for simple sequence repeats from expressed sequence tags of zebrafish, medaka, Fundulus, and Xiphophorus. In Silico Biology. 5(5-6):439-463
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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