Gene

lrpap1

ID

ZDB-GENE-030131-5871

Name

low density lipoprotein receptor-related protein associated protein 1

Symbol

lrpap1 Nomenclature History

Previous Names

wu:fi20f07
wu:fi22c06

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have heparin binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Is expressed in neural tube; otic placode; and pronephric duct. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56655 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Liu et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrpap1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myopia	Alliance	Myopia 23, autosomal recessive	615431

Associated With lrpap1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
myopia	lrpap1^{zf3843/zf3843}	standard conditions	Liu et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009066	Alpha-2-macroglobulin receptor-associated protein, domain 1
Domain	IPR010483	Alpha-2-macroglobulin RAP, C-terminal
Domain	IPR037999	Alpha-2-macroglobulin RAP, domain 3
Domain	IPR038001	Alpha-2-macroglobulin RAP, domain 2
Family	IPR038003	Alpha-2-macroglobulin receptor-associated protein
Homologous_superfamily	IPR036744	RAP domain superfamily