ZFIN ID: ZDB-GENE-030131-5871
Gene Name: low density lipoprotein receptor-related protein associated protein 1
Gene Symbol: lrpap1    Nomenclature History

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Previous Names: wu:fi20f07, wu:fi22c06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have lipase binding activity; lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to be involved in negative regulation of receptor internalization and negative regulation of very-low-density lipoprotein particle clearance. Predicted to localize to several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in neural tube; otic placode; and pronephric duct. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1).
Genome Resources: Alliance (1),  Gene:333939 (1),  Ensembl(GRCz11):ENSDARG00000033604 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:56655]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021187Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31217 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko775a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko775b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lrpap1 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lrpap1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    myopia Alliance Myopia 23, autosomal recessive 615431
    DISEASE ASSOCIATED WITH lrpap1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of receptor internalization (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function heparin binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lrpap1-201 (1)    Ensembl 2123
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lrpap1 No data available
    MARKER RELATIONSHIPS
    lrpap1 Contained in: [BAC] CH211-164D19 (1)
    lrpap1 Encodes: [EST] fi20f07 (1), fi22c06
    [cDNA] MGC:56655 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201306 (1) 2109 nt
    Genomic GenBank:BX511116 (1) 52397 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QMD9 (1) 345 aa
    Sequence Information (all 14)
    ORTHOLOGY for lrpap1 ( Chr: 1 )
    CITATIONS (31)